MabSelect™ PrismA™ protein A chromatography resin

MabSelect PrismA™ resin is available for immediate delivery.

MabSelect PrismA™ affinity chromatography resin has been improved with an optimized high-flow agarose base matrix and a genetically engineered protein A-derived ligand. This allows future demands in mAb purification to be met, including processing of many bispecific antibodies.

• Enhanced dynamic binding capacity allows high mass throughput of processed mAb per resin volume unit.
• Excellent alkaline stability enables efficient cleaning and sanitization using 0.5–1.0 M NaOH for improved process economy, bioburden control, and robustness.
• Covered by a comprehensive security of supply program, including dual sources of the agarose base matrix and protein A ligand.
• The PrismA protein A ligand is also available in HiTrap Fibro™ and HiScreen Fibro™ PrismA chromatography units for ultrafast purification of mAbs.
• Easily measure protein A leakage using the PrismA ELISA kit specifically designed for use with MabSelect PrismA™ resins.

The enhanced alkaline stability of MabSelect PrismA™ also provides opportunities for more robust mAb purification using periodic counter-current chromatography. The possibility for cleaning using 1 M NaOH increases bioburden control for continuous processes, which can be exposed to days or weeks of feed harvest.

For samples, contact your local sales representative or customer support.

MabSelect PrismA™ protein A resin builds on the proven track record of MabSelect™ and MabSelect SuRe™ resins in downstream processing of monoclonal antibodies.

• Learn about ReadyToProcess MabSelect PrismA™, prepacked HiScreen MabSelect PrismA™, HiTrap MabSelect PrismA™, PreDictor MabSelect PrismA™ or PreDictor Robocolumns MabSelect PrismA™.
• Learn how Bispecific antibodies (BsAb) can be purified using protein A chromatography in only a single step.
• Learn about large scale column packing using MabSelect PrismA™.
• Learn about reducing bioburden and sanitization of MabSelect PrismA™