PRIMO
Custom micropatterning for cell control
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Control the chemistry and topography of cell microenvironment and study their impacts on cell development, using a contactless and maskless quantitative photopatterning solution.
Take control of the cell microenvironment - PRIMO was developed to enable you to design and conduct all the micropatterning experiments you can imagine, in 2D and also 3D.
Simply select the pattern you want to use from your computer files (no size or shape limitations). Primo then projects it onto the cell culture substrate and allows you to generate the pattern with the protein of your choice.
PRIMO micropatterning technology - Studying the influence of the microenvironment on intracellular and intercellular mechanisms has been essential for research in cell and medical biology, for many years now.
Among the methods to control this microenvironment is a rapidly developing process called “micropatterning”, which involves creating protein patterns upon which living cells are cultivated. However, current micropatterning techniques are tedious, complex and non-quantitative.
Based on this finding, the scientists at Alvéole developed an innovative multi-protein photopatterning technique to make experimental manipulations easier for researchers.
The PRIMO technique is based on LIMAP technology (Light Induced Molecular Adsorption of Proteins) and combines a maskless and contactless photolithography system (PRIMO) controlled by a dedicated software (named “Leonardo”) and a specific photoactivatable reagent (PLPP). The combined action of UV and PLPP makes it possible to generate, in only a few seconds, any multi-protein pattern on standard cell culture substrates.
