Products & ReviewLife Sciences
Purmorphamine
Hedgehog pathway activator; Activates Smoothened (SMO)
Purmorphamine
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Purmorphamine is a tri-substituted purine derivative that activates the Hedgehog pathway by directly binding to and activating the Hedgehog receptor Smoothened (EC₅₀ = 1 µM). (Sinha and Chen)
DIFFERENTIATION
- Promotes differentiation of ventral spinal progenitors and motor neurons from human pluripotent stem cells (Hu and Zhang, Karumbayaram et al., Li et al.).
- Promotes differentiation of osteoblasts from human and mouse mesenchymal cells (Beloti et al., Wu et al. 2002, Wu et al. 2004).
- Inhibits differentiation and maturation of adipocytes from human mesenchymal cells (Fontaine et al.).
