Resveratrol

Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity (Rotondo et al.). Resveratrol is also a selective inhibitor of cyclooxygenase-1 (COX-1; Jang) with an ED₅₀ value of 15 μM, respectively.

MAINTENANCE AND SELF-RENEWAL

• Inhibits differentiation of pig preadipocytes into adipocytes (Bai et al.).
• Promotes self-renewal of human mesenchymal stem cells (Peltz et al.).

DIFFERENTIATION

• Induces osteogenic differentiation in human bone marrow-derived mesenchymal stem cell cultures (Boissy et al.; Dai et al.; Peltz et al.).
• Induces osteoblast differentiation while blocking adipocyte development in mouse mesenchymal stem cells and cultured primary rat bone marrow cells (Bí¤ckesjö et al.).