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Streptozocin

Merck KGaA, Darmstadt, GermanyS0130Available: Worldwide

≥75% α-anomer basis, ≥98% (HPLC), powder  

Merck KGaA, Darmstadt, Germany

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BIOLOGICAL INTERVENTION

Diabetes is induced by streptozotocin (STZ), a glucosamine–nitrosourea compound derived from Streptomyces achromogenes that is used clinically as a chemotherapeutic agent in the treatment of pancreatic β cell carcinoma. STZ damages pancreatic β cells, resulting in hypoinsulinemia and hyperglycemia.

Review Date: 13 Jul 2022 | Merck KGaA, Darmstadt, Germany

Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.

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