Products & ReviewLife Sciences
Tnfrsf17(BCMA)
Recombinant Human B-cell Maturation Antigen (BCMA/TNFRSF17), a TNF receptor superfamily member that is a clinically validated target for multiple myeloma therapies.
Tnfrsf17(BCMA)
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BCMA is selectively expressed on mature B lymphocytes and plasma cells. It binds BAFF and APRIL, promoting B-cell survival. Its high expression on malignant plasma cells in multiple myeloma has made it a leading target for CAR-T cell therapies (e.g., Abecma, Carvykti) and antibody-drug conjugates.
Key Features & Benefits:
- High Purity and Functional Activity
- Binds BAFF and APRIL Ligands
- Critical Reagent for CAR-T and ADC Development
- Multiple Formats (Monomeric, Fc-fusion)
Relevant Applications:
- CAR-T Cell Binding and Potency Assays (for Multiple Myeloma)
- Anti-BCMA Antibody and ADC Screening
- Study of Plasma Cell Biology and Survival
- Biomarker for Multiple Myeloma
