Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.
ToxCount™ provides a two wavelength cell viability assay based on determination of live and dead cells. The assay uses fluorescent dyes that measure permeability of the plasma membrane of dying cells and the ability of living cells to retain intracellular esterases, respectively. Live cells are distinguished by the presence of ubiquitous intracellular esterase activity, determined by the enzymatic conversion of the non fluores…
ELISA-based assay for the detection and quantification of global DNA methylation in human genomic DNA
Simple plate-based non-radioactive DNA-binding assays that facilitate the study of NFkB transcription factor activation in mammalian tissue and cell extracts
Simple solution for studying Nrf2 activation in human, mouse and rat model systems
Highly sensitive and rapid microplate-based assay to simplify the measurement of DNA methyltransferase activity
ELISA-based assay designed to detect and quantify 5-hydroxymethylcytosine (5-hmC) levels in genomic DNA from different sample types
Multiplex epigenetic assay for high throughput profiling of histone post-translational modifications
Simple, sensitive method for detecting changes in histone methylation levels from purified core histones or histones isolated by acid extraction
