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ChemiScreen™ alpha2A Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human--2A-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant alpha2A expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between-alpha2A and its ligands.

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ChemiScreen™ S1P3 Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human S1P3-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant S1P3 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway.

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ChemiScreen™ EP1 Calcium-Optimized FLIPR Cell Line

Merck

Chemicon's cloned human EP1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant EP1 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to enhance coupling of the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between EP1 and its ligands.

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ChemiScreen™ δ Opioid Receptor Calcium-Optimized FLIPR Cell Line

Merck

Chemicon's cloned human δ opioid - expressing cell line is made in the Chem-1 host, which supports high levels of recombinant δ opioid expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists of the δ opioid receptor

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ChemiSCREEN™ Human δ Opioid Receptor Membrane Preparation

Merck

Chemicon's δ membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of agonists and antagonists at δ. The membrane preparations exhibit a Kd of 1.12 nM for [3H]-DADLE. With 0.9 nM [3H]-DADLE, 10 µg/well δ Membrane Prep typically yields greater than 4-fold signal-to-background rati…

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CHEMISCREEN™ MEMBRANE PREPARATION RECOMBINANT HUMAN µ (Mu) OPIOID RECEPTOR

Merck

Chemicon's µ opioid receptor membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of µ opioid receptor interactions with its ligands. The membrane preparations exhibit an EC50 of 1.6nM for DAMGO in a GTPγS binding assay.

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ChemiScreen™ Human D1 Dopamine Receptor Calcium-Optimized FLIPR Cell Line

Merck

Chemicon's cloned human D1-expressing cell line is made in the Chem-6 host, which supports high levels of recombinant D1 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between D1 and its ligands.

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ChemiSCREEN™ Human D3 Dopamine Receptor Membrane Preparation

Merck

Chemicon's D3 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of D3 interactions and its ligands. The membrane preparations exhibit a Kd of 0.1 nM for [125I]-Iodospiperone. With 5.0ug/well D3 membrane prep and 0.1 nM [125I]-Iodospiperone, a greater than 4-fol…

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ChemiSCREEN™ Membrane Preparation Recombinant Human β1 Adrenoceptor Receptor

Merck

EMD Millipore's β1 adrenoceptor membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of β1 adrenoceptor interactions. The membrane preparations exhibit a Kd of 2.6 nM for [125I]-(-) Iodocyanopindolol (ICYP). With 5 µg/well β1 Adrenoceptor Membrane Prep and 0.25 nM…

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ChemiScreen™ 5-HT1A Serotonin Receptor Calcium-Optimized FLIPR Cell Line

Merck

Chemicon's cloned human 5-HT1A-expressing cell line is made in the Chem-3 host, which supports high levels of recombinant 5-HT1A expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between 5-HT1A and its ligands.

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ChemiSCREEN™ Membrane Preparation Recombinant Human 5-HT1B Serotonin Receptor

Merck

EMD Millipore's 5-HT1B membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of agonists and antagonists of 5-HT1B. The membrane preparations exhibit a Kd of 10.5 nM for [3H]-GR125743. With 7 nM [3H]-GR125743, 10μg/well 5-HT1B Membrane Prep typically yields greater than 8-fold si…

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ChemiScreen™ CALCIUM-OPTIMIZED STABLE CELL LINE HUMAN RECOMBINANT GLUCAGON RECEPTOR

Merck

Chemicon's cloned human Glucagon Receptor-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant Glucagon Receptor expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between the Glucagon Receptor and its ligands…

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ChemiScreen™ Recombinant Human Glucagon Receptor Membrane Preparation

Merck

Chemicon's glucagon receptor membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of glucagon receptor interactions and its ligands. The membrane preparations exhibit a Kd of 3.09 nM for [125I]-glucagon. With 1 nM [125I]-glucagon, 5 or 10 μg/well glucagon receptor…

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ChemiScreen™ CALCIUM-OPTIMIZED STABLE CELL LINE HUMAN RECOMBINANT M2 MUSCARINIC ACETYLCHOLINE RECEPTOR

Merck

Chemicon's cloned human M2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant M2 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between M2 and its ligands.

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ChemiScreen™ Human recombinant GABAB1b/ GABAB2Receptor, Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human GABAB1b/GABAB2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant GABAB1b/GABAB2 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between GABAB and its ligands.

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ChemiSCREEN™ Membrane Preparation Recombinant Human GABAB1b/GABAB2 Receptor

Merck

Chemicon's GABAB1b membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of GABAB1b receptor interactions with its ligand. The membrane preparations exhibit a Kd of 1.15nM for [3H]-CGP 54626A. With 5.0 ug/well GABAB1b Membrane Prep and 7.5nM [3H]-CGP 54626A, a grea…

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ChemiScreen™ Human recombinant SST4 Somatostatin Receptor, Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human SST4-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant SST4 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between the SST4 and its ligands.

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ChemiScreen™ Human Recombinant LPA3 Lysophospholipid Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human LPA3-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant LPA3 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between LPA3 and its ligands.

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ChemiScreen™ Human Recombinant 5-HT2C Serotonin Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human 5-HT2C -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant 5-HT2C expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between 5-HT2C and its ligands.

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ChemiSCREEN™ Membrane Preparation Recombinant Human GIP Glucagon Family Receptor

Merck

EMD Millipore's GIP membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of agonists and antagonists at GIP Receptor. The membrane preparations exhibit a Kd of 0.44 nM for [125I]-GIP. With 0.2 nM [125I]-GIP, 10 µg/well GIP Receptor Membrane Prep typically yields greater than 8-f…

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