Drug discovery > Basic Research Products & Reviews
Products, services, reviews and techniques used in the preliminary investigations of the disease; the cell biology, genetics and protein pathways using tissue culture, cloning and imaging.
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GFP-/RFP Booster
Chromotek GmbHGFP/RFP-Booster – enhance your fluorescent fusion protein ChromoTek’s Booster are very small, highly specific GFP- or RFP-binding proteins covalently coupled to the superior fluorescent dyes from ATTO-TEC. With our Booster you can: • Reactivate • Boost • Stabilize the signals of your fusion proteinsDirectly stain your protein of interest in fixed cells and benefit from the high specificity an small size that are perfect for su…
Chromobodies®
Chromotek GmbHChromobodies® - Your perfect reagents for cellular research including High-Content Analysis. Chromobodies are fluorescent nanoprobes suitable for real time analyses of endogenous cellular structures and processes in live cells. Chromobodies® are a novel species of extremely small intracellular antibodies. They are based on the antigen binding domain (VHH) derived from heavy chain antibodies of camelids genetically fused to a f…
Epigenetic Toolbox
Chromotek GmbHDNA methylation was the first epigenetic modification identified and has been intensively studied for more than half a century. By now it is clear that Dnmt1, the major eukaryotic DNA methyltransferase, faithfully maintains genome-wide methylation patterns and plays an essential role in the epigenetic network controlling gene expression and genome stability during development. However, the molecular mechanisms that ultimately…
Cell Cycle Toolbox
Chromotek GmbHProliferating cell nuclear antigen (PCNA) is a homotrimeric ring-shaped protein that encircles DNA and acts as a loading platform for multiple, transiently interacting factors participating in various DNA transactions. PCNA plays a key role in DNA replication, repair, cell cycle regulation, and post-replicative transactions like DNA methylation and chromatin remodeling. All these cellular processes are regulated by a complex n…
Cell Organelle Toolbox
Chromotek GmbHBeing able to visualize endogenous cellular structures in live cells is key for many high content analyses. The two Chromobodies® of the ChromoTek’s Cell Organelle Toolbox offer a new way to investigate key compartments of the cell non-invasively. Lamin-Chromobody® The new Lamin-Chromobody® is a major breakthrough especially in High-Content Analysis (HCA) as apoptosis assays thus far rely on static endpoint assays. The nucle…
Visitron TIRF system
Photon Lines LtdThe VisiTIRF Fluorescence Imaging System from Visitron Systems is the ideal solution for the analysis of finest structures or surfaces. The flexibility of the VisiTIRF system and the use of scientific digital CCD camera systems with optimal resolution, speed and sensitivity allows for the adaptation of customized application and configuration. For fluorescence illumination Visitron use solid state lasers or laser diodes . The…
Micro-Incubation System (DH-40iL)
Warner Instrument Corp.The DH-40iL Microincubator is designed for imaging live cells under constant temperature and atmospheric conditions. This versatile incubation system enables high resolution image analysis, fluorescence microscopy, and time-lapse imaging studies while accommodating both upright and inverted microscopes. Designed to provide complete environment control for either the Series 40 open bath chambers or 35 mm cell culture dishes. E…
Bold Line Top Stage Incubator H301
OkolabThe Bold Line Top Stage Incubator H301 is the latest release from OKOLAB in terms of Top Stage incubation. It delivers superior temperature stability, humidity, CO2 and Oxygen control in a fully integrated fashion. The Bold Line Top Stage Incubator H301 Equipment: Incubating Chamber: fits in the microscope stage and holds the specimen. It is equipped with heated glass lid and Temperature and Humidity sensors. T Unit: Bo…
Water Jacket Top Stage Incubator H101
OkolabThe Water Jacket Incubator provides superior incubation stability above and below room temperature. Water is pumped from a water bath into the base plate and into the lid, which are both Water Jackets. Temperature Control Mechanism Temperature is directly measured inside a reference Petri-dish and is controlled by circulating water from a water bath into the Water Jacket Chamber. The Temeprature Controller reads the temperatur…