Drug discovery > Lead Discovery Products & Reviews

High resolution XBridge Oligonucleotide BEH C18 OBD Prep Column, 130Å, 2.5 µm for purfication of oligo nucleotides.

Size-based separations of peptides. proteins, and viral vectors

Size-based separations of peptides, proteins, and viral vectors

Reversed-phase based separations of peptides

The ChromaLynx™ Application Manager automates the processing of LC/MS or GC/MS and LC/MS/MS or GC/MS/MS data. While the high chromatographic separation efficiency and narrow peak widths typical of GC/MS often increase the challenge to identify co-eluting components, ChromaLynx facilitates the rapid detection, identification and semi-quantitative determination of all components. Manually reviewing complex chromatograms to locat…

Achieve faster run times and improved sensitivity with a smaller particle size

ACQUITY UPLC® BEH Phenyl columns utilize a trifunctional C6 alkyl tether between the phenyl ring and the silyl functionality. This ligand, combined with the same proprietary endcapping processes as the ACQUITY UPLC™ BEH C18 and C8 columns, provides ultra-low column bleed, long column lifetimes and excellent peak shape. This unique combination of ligand and endcap on the 1.7 μm BEH particle creates a new dimension in selectivi…

Waters offers a broad range of vials, each one is held to tight dimensional tolerances and the certified products have cleanliness measured by LC and MS.LC/GC Certified vials are tested by LC/UV for residues of chemicals used in processing and packaging vials. The septa are tested by headspace GC to ensure low levels of low molecular weight polymer. These vials are suited for analyte concentration in the µg/mL concentration; t…

The Waters IdentityE High Definition Proteomics system defines the new standard for rigorous protein identification. The IdentityE High Definition Proteomics System is an UltraPerformance LC® (UPLC)/High-Bandwidth Mass Spectrometry (MS E) system solution suitable for confident protein identification designed to meet stringent requirements as outlined by leading scientific journals.The new Waters IdentityE High Definition Pro…

The ACQUITY UPLC® Fluorescence (FLR) Detector brings unrivaled sensitivity and selectivity to UPLC®. The detector’s innovative flow-cell design, low-noise electronics and support for high-speed data rates are perfectly suited to the efficient separations of the ACQUITY UPLC's advanced fluidics technology. Target applications include PAHs, environmental contaminants, vitamins, aflatoxins and pharmaceuticals. Ultra Performance i…

SymmetryShield™ Columns feature Waters' patented embedded polar group technology that shields the silica's residual silanols from highly basic analytes at improves overall peak shape. Additionally, by placing the embedded polar group close to the silica surface, the activity of the surface silanols is further reduced. This imparts selectivity and retention that is different compared to the Symmetry C18 ligand. Embedded polar…

Reversed-Phase Protein/Peptide Columns

Over 50 years of reproducible performance

Semi-preparative Columns with excellent batch-to-batch reproducibility

Polynuclear Aromatic Hydorcarbons (PAHs) are among the most frequently monitored environmental contaminants. Waters PAH columns are optimized for the HPLC analysis of PAHs. These columns achieve baseline resolution and excellent peak symmetry for 16 different target analytes in less than 25 minutes, while employing a simple water/acetonitrile binary gradient method. The resolving power of the PAH columns provides superior pe…

The popular Bondapak® C18 chemistry and Porasil® silica packing material are available in three different particle sizes, 10, 15-20, 37-55 micron, providing easy transfer of chromatography methodology from one particle size to another. You can utilize your existing 10 micron Bondapak or Porasil chromatography as a starting point for scale-up or, if you are developing a new purification protocol, investigate which preparative…

These columns provide accurate and precise molecular weight calculations in under 7 minutes! - Fast, accurate and precise molecular weight determinations - Increase sample throughput - Greatly decrease solvent consumption and disposal

The Envirogel high-efficiency GPC cleanup columns are specifically designed to remove low volatility, high molecular weight interferences, such as lipids and natural resins, from environmental samples as specified in EPA Method 3640A. In the past, the cleanup procedure for environmental samples was performed on low-efficiency GPC columns based on packing particle diameters of 37-75 micron (200 to 400 mesh) Bio-Beads S-X resins…

For applications where the sample is neither volume or concentration limited, Waters offers 1 and 2mm Internal Diameter columns of various lengths for use on traditional HPLC MS inlets.As with Waters array of NanoEase™ columns, the same Waters reversed-phase packings are also available in these two column internal diameter offerings. Chemistry choices include: XBridge® Columns, CORTECS® Columns, XSelect Columns, Atlantis® Pola…

MassPREP™ On-Line Desalting Cartridges are an effective tool for the successful desalting of acidic, basic, and large globular proteins. The overall MassPREP™ desalting strategy provides an easy, fast (< 3 minutes), and reproducible approach for the effective desalting of proteins stored in physiological salt buffers prior to high resolution ESI-MS structural analysis.

Waters offers PoraPak™ Rxn, a family of polymer-based chromatography products for superior cleanup of synthetic reactions. PoraPak Rxn products are available in two chemistries: PoraPak Rxn CX, a strong cation-exchange sorbent and PoraPak Rxn RP, a reversed-phase sorbent.PoraPak Rxn sorbents are based on copolymers that exhibit the following properties:Hard material that does not develop increasing back pressure with flowLitt…

Developed for your most demanding LC/MS/MS quantitative applications, the Quattro Premier™ XE tandem quadrupole mass spectrometer features the highest levels of sensitivity, selectivity, robustness, speed and accuracy. To maximize the analytical advantages of your ACQUITY UPLC® System, the Quattro Premier XE operates at the highest data acquisition rates. Together, the ACQUITY UPLC® System and the Quattro Premier XE give you i…

DisQuE Dispersive Sample Preparation is a well proven, high throughput sample preparation method for a wide array of pesticides in produce. The kit contains conveniently packaged vials with pre-measured sorbents and buffers used to provide extraction and clean-up for up to 100 samples. Each 50 mL DisQuE Extraction tube contains 6 grams of magnesium sulphate and 1.5 grams of sodium acetate. Each 2 mL DisQuE Clean-Up tube cont…

The Mass Spectrometry Primer, an 82-page paperback book, covers a wide range of topics related to the most wide spread of modern mass spectrometry practices and answers some frequently asked questions about the use and capabilities of mass spectrometers. Links are also provided to articles for more in-depth reading. The first section examines who uses mass spectrometers, followed by how compounds are ionized in the source to b…

The 515 HPLC pump is a programmable, free-standing HPLC pump available in isocratic, gradient, and semi-preparative configurations: • Precise stepper motor control (48 steps/µL resolution) of dual reciprocating pistons • Non-circular drive gears provide smooth, uniform eluent delivery • User-programmable flow rate calibration and compressibility compensation factors ensure straightforward pump operation qualification • Tests t…