Process chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.
The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes. Model Properties: Coat Color: Black Ideal For: Cardiac hypertrophy, heart failure Strain Code: 510 HE,…
NSE-p25 mice were created by pronuclear injection of an NSE-p25 transgene, produced internally at Pfizer, with transplantation of embryos to pseudopregnant CD-1 females. At weaning genomic DNA was isolated from tail tissue and founder transgenics were identified by PCR that specifically amplified DNA sequences from the human p25 cDNA. Founder mice were bred to FVB/N mates and transgenic offspring were used to maintain the tra…
Developed by C.C. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Strains 6 and 10 separated about 1937. To Hall in 1948 from The Jackson Laboratory. To NIH in 1951 from The Jackson Laboratory at F32. To Charles River in 1974 from NIH. Model Properties: Coat Color: Black MHC Haplotype: H2b Ideal For: general multipurpose model, diet-induced obesity, transgenic…
Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976. Model Properties: Coat Color: Non-agouti brown MHC Haplotype: RT1n Ideal For: Geneti…
The New Zealand White rabbit was obtained in 1991 by Charles River Canada (CRC) from Kitayama Labs K.K. of Nagano Prefecture, Japan. Model Properties: Coat Color: White (albino) Ideal For: General multipurpose model Strain Code: 052
Optim is an innovative analytical instrument designed to probe multiple protein stability-indicating parameters at high speed using ultra-low sample volumes of proteins and other molecules. Compact and robust, using a light scattering and fluorescence technology in a configuration never seen before and controlled by an all-new easy-to-use intuitive software package, the Optim 2 has been designed to reduce the time and cost of…
Formulation Development SpecialistsWith a keen understanding of early stage development and clinical trial requirements, Aesica guides their customers through the processes of new medicine and material development for Phase 1 and Phase 2 clinical trials. They understand that their customers also need to maximise their budget effectiveness by minimising the amount of experimentation without sacrificing quality levels.Typical do…
In the fast growing Biopharma market, the need for ultra clean sterile packaging is growing at a high speed, often driven by regulatory authorities and cGMP regulations. Eliminating every risk of delivering a contaminated parenteral drug that might be hazardous to a patient's health or even his life is the key concern that drives these regulations.The source for all your Cleanroom Packaging - with the Newform™ product line, r…
Marken’s network fulfills the global movement of API from the point of manufacturing to CMOs and primary packagers. Marken optimizes API logistics around the globe with continuous temperature monitoring, documented transit custody and a worldwide network of offices, providing end-to-end quality-assured supply chain services.With Marken’s experience and expertise they excel in assisting companies to achieve the most expeditiou…
Marken offers validated packaging solutions for the widest range of temperatures to ensure that your products maintain their integrity throughout the shipment. BIOsystem boxes are designed and engineered specifically for the transportation of frozen and controlled ambient biologics. Your samples have specific temperature profiles that must be strictly maintained to preserve their efficacy. Marken is uniquely qualified to prov…
