Products & ReviewLife Sciences
Zoledronic Acid
Inhibitor of bone resorption; Inhibits farnesyl diphosphate (FPP) synthase
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Zoledronic acid is a nitrogen-containing bisphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC₅₀ = 5 nM), thereby preventing protein prenylation and osteoclast-mediated bone resorption (Dunford et al.). In addition, it has a high affinity for hydroxyapatite (Ki = 3.5 μM) which allows it to bind directly to mineralized bone (Nancollas et al.). This product is supplied as the hydrate form of the molecule.
CANCER RESEARCH
- Inhibits proliferation, angiogenesis, and adhesion to bone, in several cancer cell lines (Li & Davis; Zekri et al.).
- Inhibits breast and prostate carcinoma cell invasion in vitro (Boissier et al.; Li & Davis).
- Induces apoptosis of osteoclastoma cells in vitro (Benford et al.).
