UHPLC and HPLC Products & Reviews

The Ultra line represents Restek’s broadest selection of stationary phases on a single silica support. Made of high-purity, type-B silica that minimizes activity and creates high-density bonding, the Ultra Cyano Columns (USP L10) are designed for selective and reliable HPLC applications.Particle size: 3 μm or 5 μm, spherical Pore size: 100 Å Carbon load: 8% End-cap: yes pH range: 2.5 to 8 Temperature limit: 80 °C USP phase co…

The Ultra line represents Restek’s broadest selection of stationary phases on a single silica support. Made of high-purity, type-B silica that minimizes activity and creates high-density bonding, Ultra Silica Columns (USP L3) are designed for selective and reliable HPLC applications. Particle size: 3 μm or 5 μm, spherical Pore size: 100 Å End-cap: no pH range: 2.5 to 8 Temperature limit: 80 °C USP phase code: L3 Phase catego…

Viva columns are based on a wide pore material we designed for optimal large-molecule separations.In developing Viva silica, we found that although many commercial wide-pore silicas meet the standard 300 Å mean pore size, most have very broad distributions about this mean, with a significant portion of their pore volume falling below 150 Å.This means a large portion of the surface area is unavailable to larger molecules. Viva…

Use our bulk packing materials to pack your own columns. Our extensive QC program ensures the high quality and reproducibility of these silicas. You can be confident that you are getting consistent, high-quality product when you source your silica from Restek. Use these materials for easy scale-up to preparative chromatography or for packing your own columns. Ultra Bulk Packing Materials Features: Prepare your own columns…

Get more of what you want, and less of what you don't, with Roc™ LC columns from Restek.

Force LC columns are available with Restek's most popular and highly selective Biphenyl and FluoroPhenyl phases, as well as a general-purpose C18.

Restek's Raptor FluoroPhenyl column offers the ability to run in reversed-phase or HILIC mode for a variety of compounds. It is ideal for increasing sensitivity and sensitivity in LC-MS analyses. 

The Allure Acrylamide LC column provides targeted acrylamide retention as well as improved isolation from matrix interferences.

TSKgel HIC-ADC columns are novel analytical solutions to rapidly characterize the drug-antibody ratio (DAR) for antibody drug conjugates (ADCs). Available in butyl and phenyl hydrophobicities with additions to the column family on the way, the TSKgel HIC-ADC column line has you covered for fast ADC analysis.

Rapid at-line analytical chromatography solution for all stages of mRNA production, purification, and quality assessment.

Innovative solution that enables investigation of multiple critical attributes for LNP drug products, without extensive sample preparation or dye requirements.

A tool for chromatographic purification of LNPs as an alternative to filtration methods.

The patent-pending EXP® Trap Column is rated for use at 20,000+ psi (1,400+ bar). This unique design connects directly to any injection valve (with 10-32 threads) or in-line with 1/16” stainless tubing for unparalleled convenience and efficiency. The EXP® Cartridge System enables chemists to quickly remove detergents or salts which can affect the ionization process in MS work. This trapping technique can concentrate the sampl…

OPTI-MAX® Cartridge Check Valves are designed to offer maximum performance and ease of use. From the sharp, consistent threads on OPTI-MAX® custom housings, to the exacting standards used to match ball/seat sets in OPTI-MAX® cartridges, every aspect of design and manufacturing reflects an unavoidable fact: when it comes to reliable check valve operation, quality and precision make a big difference. OPTI-MAX® check valves offer…

The entire EXP® Stem Trap and reusable holder are only slightly larger than a standard HPLC fitting. Its slim architecture allows it to easily fit into crowded instrument compartments or to connect directly to tightly-spaced injection ports. When tightened by hand, the EXP® Stem Trap seals to 8,700+ psi. All configurations incorporate wrench-flats to enable flawless sealing to 20,000+ psi (1,400+ bar). The unique packed floati…

The EXP® Fitting System is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the swage can be released without tools to a…

The EXP® Hex Head Nut & Titanium Hybrid Ferrule fitting system is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the s…

The EXP® Hand Tight Coupler is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the swage can be released without tools…

The EXP® Stem Filter features a choice of frit porosities integrated with our patented auto-adjusting stem for repeated ZDV connections with any 10-32 port. The entire filter stem and reusable holder are only slightly larger than a standard HPLC fitting. This slim architecture allows it to easily fit into crowded instrument compartments, tightly spaced injection ports, and anywhere else you need an extra level of protection ag…

The EXP® Nano Trap System is designed to remove detergents or salts which can affect the ionization process in MS work rated for routine use up to 20,000 psi.The new nano-scale traps are available in two formats – EXP® Nano Trap and EXP® Nano Trap HR. Both formats are available in 10 or 20 mm lengths and in a variety of bed volumes ranging from 0.25µL - 4.0µL. The EXP® Nano Trap follows a traditional trap column format, design…

The EXP® Hand Tight Nano Fittings System offers hand-tight and hex head adjustable nut and ferrule compression fittings for extreme pressure connections between 1/32” stainless steel tubing and 6-40 ports.Ideal for nano-scale UHPLC and UHPLC/MS, this nut and ferrule compression fitting is rated to 20,000+ psi (1400+ bar). The patent-pending EXP® 1/32” Titanium Hybrid Ferrule combines the sealing capability of PEEK and robust n…

The EXP® Nano Fittings System offers hand-tight and hex head adjustable nut and ferrule compression fittings for extreme pressure connections between 1/32” stainless steel tubing and 6-40 ports.Ideal for nano-scale UHPLC and UHPLC/MS, this nut and ferrule compression fitting is rated to 20,000+ psi (1400+ bar). The patent-pending EXP® 1/32” Titanium Hybrid Ferrule combines the sealing capability of PEEK and robust nature of ti…

OPTI-MAX® Cartridge Check Valves are designed to offer maximum performance and ease of use. From the sharp, consistent threads on OPTI-MAX® custom housings, to the exacting standards used to match ball/seat sets in OPTI-MAX® cartridges, every aspect of design and manufacturing reflects an unavoidable fact: when it comes to reliable check valve operation, quality and precision make a big difference. OPTI-MAX® check valves offer…

OPTI-SOLV® Reservoir Filters employ a unique conical design inside the filter housing to prevent air bubbles from getting trapped and disturbing your analysis. While the availability of HPLC-grade solvents diminishes the need for pre-filtering, it is still imperative that a filtration device be installed in the reservoir. Placing a filter in the reservoir is an economical way to filter particles that may result from buffer sal…

A solid PTFE body keeps OPTI-SOLV® filter at the base of the bottle where a bottom-mounted titanium frit provides unrestricted solvent access. As always, Optimize makes installation as simple as possible - no tools or fittings required and includes 5 feet of pre-installed PTFE tubing. OPTI-SOLV Reservoir Filters employ a unique conical design inside the filter housing to prevent air bubbles from getting trapped and disturbing…