Assay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.
PBL's bioassays for interferons are cytopathic effect inhibition assays, also known as CPE and antiviral assays. The neutralization assay measures the antibody's ability to neutralize the CPE activity of the cytokine. Sample types include; tissue culture supernatents; serum and delivery formulations. In these assays, one unit is defined as the quantity of interferon required per milliliter to reduce the cytopathic effect of vi…
Real-Time qPCR assays for kinases and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Real-Time qPCR Case, Immersion Fluid, Frame Adhesive and Plate-File CD.
Virtual tissues services for biomedical research features high fidelity tissue simulation and modelling to grow virtual tissue from a single cell, giving unprecedented insight into lineage commitment phenomena of stem cells with insight into signalling pathways and detailed gene regulatory networks.With Endogenics complementing traditional techniques, researchers can simulate human cell development and tissue organization and…
R&D Proteome Profiler Human Phospho-Kinase Array Kit - Human Phospho-Kinase Array Kit for the parallel determination of the relative levels of protein phosphorylation. The kit contains 4 sets of 2 membranes - each spotted in duplicate with 46 different kinase antibodies. The R&D Human Phospho-Kinase Array is a rapid, sensitive, and economical tool to simultaneously detect the relative levels of phosphorylation of 46 kinase ph…
R&D Systems Recombinant SCF Protein Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. Specifications and Use for R&D SC…
SIRT1 belongs to the class III family of HDACs, which are NAD+ dependent enzymes. SIRT1 modulators have been shown to play a beneficial role in treating diseases such as cancer, diabetes, metabolic disease and inflammation, making them attractive targets for the development of new drugs. The new HTRF® SIRT1 assay, developed by Cisbio Bioassays using its patented HTRF technology, is a homogeneous method for directly measuring S…
With BI-DirectFlowTM flow injection technology and Gas Phase SPR, compatible with Electrochemistry SPR The BI-3000G SPR instrument is equipped for both liquid and vapor phase SPR analyses, and utilizes a unique detection technology that delivers high sensitivity (< 10-5 degrees) and fast response times (< 0.5 ms) with superior flexibility. The innovative use of interchangeable analysis modules is specially developed to fulfill…
High Performance Surface Plasmon Resonance (SPR) Instrument The BI-2000 SPR instrument produces superior, high-quality data at a completely affordable price. BI-SPR technology utilizes a unique detection technology that delivers high sensitivity and fast response times with superior versatility in a broad range of research applications. Our innovative use of interchangeable analysis modules is specially developed to fulfill a…
G-Protein Coupled Receptors (GPCRs) are common drug targets. Previously, most studies were based on the monomeric model, but this perception of GPCRs is now evolving towards homodimeric , heterodimeric and oligomeric models. To facilitate research into GPCR dimers, CisBio Bioassays has applied the Tag-lite® technology to GPCR interaction assays. Based on HTRF® technology, plasmids have been designed to express either the SNA…
Cisbio Bioassays offer a comprehensive cellular platform to develop HTRF® ligand binding assays.Features: • Single technology and cellular platform for all GPCR assays • Unique non-radioactive ligand binding assays • Miniaturization down to < 10µl • Peptidic and non-peptidic fluorescent ligands • High Specific Binding • Low Non-Specific Binding with HTRF technology Tag-lite fluorescent ligands available for (Feb10): Vasopre…
Tag-lite® cell-lines and reagents, a multimodal environment streamlined for GPCR studies. Cellular trans-membrane receptors are high potential therapeutic targets in pharmacological research, among them G-Protein Coupled Receptors (GPCRs). To reach a better physiological understanding, their study is deepening and is now focusing on structural assessments (ligand binding, dimerisation) and also on multiple signal pathway assa…
FasL-Strep, a stable homotrimer, efficiently induces the CD95 pathway of apoptosis and is highly suited for evaluation of CD95 (Fas) receptor-ligand interaction. Human or murine FasL-Strep (CD95L-T4) is an engineered human or murine Fas (CD95) ligand. C-terminal fusion of the T4-FOLDON to the extracellular FasL (CD95L) receptor-binding domain (E142-L281) results in bioactive, conformationally stabilized, well defined trimers…
Agilent’s contract Lead Discovery Service utilizes label-free RapidFire technology for direct quantitation of a wide range of native analytes across diverse therapeutic areas. Supports SAR programs via retesting of hits. Uses your existing assays or RapidFire custom-developed assays. Quick data turnaround for faster drug discovery decisions.Screened as singletons or compressed format The ideal candidate assays are often the sa…
Cell Membranes - Custom Preparation of Cell Membranes from CCS Cell Culture Service Preparations membranes from cell which are expressing a target receptor, transporter or ion channel at a high density are a useful tool in drug research. Embedded in a membrane fragment or vesicle the proteins remain in a functional native confirmation. Ligand binding assay and functional GTP-gammaS assays can be performed with these preparati…
Frozen membranes from CHO-K1 cells expressing recombinant human Alpha2b Adrenergic receptors. (Cat#: A104)
Frozen membranes from CHO-K1 cells expressing recombinant human FPRL1 N-Formyl Peptide receptors. (Cat#: A121)
Frozen membranes from HEK293 cells expressing recombinant human Thromboxane receptors. (Cat#: A127)
Frozen membranes from CHO-K1 cells expressing recombinant human SST4 Somatostatin receptors. (Cat#: A138)
Frozen membranes from CHO-K1 cells expressing recombinant human SST5 Somatostatin receptors. (Cat#: A139)
Frozen membranes from CHO-K1 cells expressing recombinant human V1a Vasopressin receptors. (Cat#: A149)
Frozen membranes from CHO-K1 cells expressing recombinant human V1b Vasopressin receptors. (Cat#: A150)
Frozen membranes from CHO-K1 cells expressing recombinant mouse 5HT2b Serotonin receptors. (Cat#: A160)
Frozen membranes from CHO-K1 cells expressing recombinant human 5HT2c Serotonin receptors. (Cat#: A161)
Frozen membranes from CHO-K1 cells expressing recombinant human Alpha2a Adrenergic receptors. (Cat#: A163)
