Biosensor Systems, Automated Products & Reviews

Label-free, real-time cell analysis in a wireless format. The RTCA iCELLigence™ instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner.  The instrument is placed in a standard CO2 cell culture incubator where it transmits data wirelessly to the Control Unit (an iPad housed outside the incubator).  User friendly s…

The Agilent xCELLigence Real-Time Cell Analysis (RTCA) MP instrument uses label-free cellular impedance to continuously monitor cell health, behavior, and function with high accuracy, sensitivity, and reproducibility.  The MP model can host up to six 96-well electronic microplates (E-Plate 96), which can be run in parallel or independently of one another. This multiple plate format is ideal for cell health characterization,…

The Agilent xCELLigence Real-Time Cell Analysis (RTCA) HT instrument uses label-free cellular impedance to continuously monitor cell health, behavior, and function with high accuracy, sensitivity, and reproducibility. Simply plate cells, add treatments, and begin monitoring cell behavior to obtain real-time kinetic data for assay windows that stretch from seconds to days.  The HT model can run a 384-well electronic micropla…

The xCELLigence RTCA Cardio instrument monitors cardiomyocyte activity for cardiotoxicity assessment. The contraction-relaxation cycle of cardiomyocytes gives rise to a distinct, rhythmic fluctuation in impedance that is readily captured on the millisecond time scale. Changes in the intensity and periodicity in impedance are monitored in seconds or in days to assess cardiomyocyte contractility and viability in the presence of…

The power of live cell imaging now combined with the sensitivity of xCELLigence Biosensor RTCA Technology

Keeping kinetics real: label-free data like you've never seen before

Live-cell analysis system

Transform biomolecular interaction analysis with Alto™, the world’s first Digital SPR™ system, featuring zero maintenance and cartridge-based characterization from ultra-low sample volumes.

Discover more “hands-off” time and rise above the noise This fluidics-free instrument can accommodate standard 96-well or 384-well microplates. With a walk-away time of >6 hours, rich datasets can be obtained with little hands-on time. Gator ® Plus is optimized for the characterization of a wide range of biomolecules including small molecule, antibodies and other proteins. Gator ® Plus enables enhanced baseline stability to p…

One and Done With 8 independent spectrometers capable of running 8 samples at once, this instrument allows for assays sizes from 1 sample to 168 samples in one run. Flexible to accommodate various applications including quantitation, kinetics, and epitope binning. Easy to use and operate, this is an instrument that everyone in the laboratory can know how to run. This is truly a plug and play instrument, taking less than 3…

The Agilent xCELLigence Real-Time Cell Analysis (RTCA) DP (dual purpose) instrument continuously measures cell invasion and migration (CIM) and monitors cell health, behavior, and function using label-free cellular impedance. The three cradles of the DP instrument enable three separate electronic 16-well plates to be controlled and monitored in parallel or independently of one another. This flexible plate batch processing a…

The Agilent xCELLigence Real-Time Cell Analysis (RTCA) SP instrument uses label-free cellular impedance to continuously monitor cell health, behavior, and function with high accuracy, sensitivity, and reproducibility. The SP model can run a 96-well electronic microplate (E-Plate 96), which is ideal for cell health characterization, immune cell-mediated killing, viral cytopathic effects, cytotoxicity, cell adhesion, cell barrie…

The performance and speed of surface plasmon resonance with the ease-of-use of a dip-in fiber-optic biosensor.

Octet® FAB2G biosensors come pre-immobilized with a high-affinity ligand that is specific for the CH1 region of Human IgG. The anti-human CH1 ligand has no recognition towards free light chains or cross-reactivity with murine or bovine IgG. This high level of specificity enables direct analysis of IgG or Fab analytes directly from complex samples such as cell culture supernatants, lysates, or partially purified samples, offer…

Octet® AHQ biosensors provide a rapid method for precise quantitation of human immunoglobulins from crude lysates and cell culture supernatants. Factory immobilization of an anti-human IgG antibody onto the biosensor surface enables direct detection of human IgG analytes with minimal sample handling and facilitates sample quantitation from cell culture screening through downstream purification development.

Octet® ProA biosensors are coated with Protein A and enable rapid antibody quantitation from crude lysates, cell culture supernatants and complex matrices.

Octet® AMQ biosensors provide a rapid method for precise quantitation of murine immunoglobulins from crude lysates and cell culture supernatants. 

Octet® APS Biosensors are coated with aminopropylsilane and provide a convenient method for hydrophobic based immobilization of most protein analytes for assaying the kinetic profile of protein-protein interactions. 

Octet® SSA (Super Streptavidin) Biosensors offer the highest sensitivity for the demands of small molecule kinetic experiments.

Octet® Anti-Human Fc Capture (AHC) Biosensors are designed for kinetic characterization of interactions between human Fc-containing proteins and target analytes. Octet® AHC Biosensors are offered in a tray format. Each tray contains 96 biosensors. Larger orders include discounts.

Octet® Anti-Mouse Fc Capture (AMC) Biosensors are designed for kinetic characterization of interactions between mouse Fc-containing proteins and target analytes. Octet® AMC Biosensors are offered in a tray format. Each tray contains 96 biosensors.

The Octet® Amine Reactive 2nd Generation (AR2G) Biosensors are designed for EDC/Sulfo-NHS based immobilization of primary amine containing biomolecules and kinetic characterization of their interactions with target analytes. The use of the AR2G Biosensors requires the Amine Coupling Second-Generation Reagent Kit (AR2G Kit, Item no.: 18-5095). Octet® AR2G Biosensors are offered in a tray format. Each tray contains 96 biosensor…

The polyhistidine protein tag (His-tag), commonly engineered into proteins during cloning, can be used to facilitate recombinant protein purification and detection by exploiting the chelating properties of histidine to an immobilized metal. The Octet® HIS1K Biosensors consist of high affinity, high specificity Penta-His antibody pre-immobilized on a fiber optic biosensor. In conjunction with the Octet® systems, the Octet® HIS…

The xCELLigence RTCA S16 instrument uses biosensors to continuously monitor live cell proliferation, morphology change, and attachment quality in a label-free and real-time manner. The instrument operates in a standard CO2 cell culture incubator and the control unit is housed outside the incubator. User-friendly software allows for real-time control and monitoring of the instrument with real-time data analysis functions.…

The xCELLigence RTCA ePacer provides an easy and effective way to produce functionally mature hiPSC cardiomyocytes. The ePacer improves the maturation status of the cardiomyocytes in 2-3 weeks using precise and electrical pacing conditions over different time durations. The simple pacing protocol, using precise and consistent electrical pacing conditions, improves the functionality of hiPSC cardiomyocytes and their response to…