MAX-BAX
Charles RiverCongenic Strain Production
Congenic strains are widely used in biomedical research because they reduce genetic variability and provide insight into the contribution of genetic background to phenotype. Congenic strains are identical at all genetic loci except for one; that differing locus is usually the transgene or knock-out region of interest. Utilizing traditional, random backcrossing methods, it takes 10 generations (upw…