Analyzing Cell Subsets and Heterogeneity from Live Cells

Considerable heterogeneity of individual cells exists even in the simplest cell system. Such heterogeneity is mirrored by the diversity of pharmacological responses at the cellular level, where even seemingly identical cells may respond differently to drug treatments and perturbagens. Hence, analysis at the cell-by-cell level promises additional biological insights beyond which whole population measures may deliver. In this white paper, we illustrate techniques of analyzing living cells over time, and describe new, industrial-scale analysis solutions for quantifying the phenotypic biology of cell subsets in heterogeneous cultures.