Class-Selective Enantiomeric Separation of β-Androgenic Receptors using CHIROBIOTIC™ T Stationary Phase

The inherent chirality of bio-organic molecules and its affect on biological activity creates a growing need for chiral separations. This application note demonstrates the chiral separation of β-androgenic receptors, a class of pharmaceutically active compounds using both UV and MS detection.

The CHIROBIOTIC T stationary phase was chosen for the study. CHIROBIOTIC T has unique selectivity for a number of classes of molecules including carboxylic acids, phenols, neutral aromatic analytes, and cyclic aromatic and aliphatic amines. Moreover, the CHIROBIOTIC T provides chiral separation using reversed-phase solvent mobile phases.