Determination of Ethyl Sulfate Impurity in Indinavir Sulfate Drug using Ion Chromatography

This work shows IC separation of ethyl sulfate in an indinavir sulfate drug sample. The method only requires the addition of DI water to the IC system to deliver reproducible chromatography while avoiding the time, labor, and potential error of manual eluent preparation. It uses an electrolytic suppressor in recycle mode, and therefore does not require the analyst to prepare sulfuric acid solutions for eluent suppression prior to conductivity detection.