Determination of Pesticides in Foods using Dopant-optimized Gas Chromatography-Atmospheric Pressure Chemical Ionization Quadrupole-Time-of Flight Mass Spectrometry

Soft ionization modes in GC-hyphenation studies such as chemical ionization (CI), field ionization (FD), supersonic molecular beam (SMB), or atmospheric-pressure chemical ionization (APCI) allows the effective formation of pseudo-molecular ions from biomolecules. GC-APCI generic source coupling is one of the more promising method as it is dually compatible with both GC and LC-hyphenated mass spectrometers. In this study, the optimization and development of a dopant-based APCI screening workflow using next-generation GC-APCI ion source on a QTOF platform for multi-target pesticide screening is presented using the Bruker Compact™ QTOF system.