Fast and Confident Identification of Drugs and their Metabolites using Ion Trap LC-MSn Analysis and a Library of >4,500 Compounds

Comprehensive screening of urine samples in forensic toxicology and clinical research is focused on the unambiguous identification of parent drugs and their corresponding metabolites. GC-MS is currently the gold standard technology in forensic screening due to the availability of large and well annotated spectral libraries. This application note presents the evaluation of a comprehensive and robust forensic toxicology LC-MSn ion trap spectral library based forensic screening solution to detect and confirm both parent drugs and metabolites in urine as alternative or complementary technology to GC-MS.