Improving drug metabolite identification in biofluids with the ACQUITY PREMIER and hybrid organic surface technology

In this application note, Waters demonstrates how the ACQUITY PREMIER System with hybrid organic surface technology was able to reduce the binding of many analyte molecules, such as phosphates, uncharged amines, hydroxyls, and deprotonated carboxylic acids, with the transition metal ions present on the metal surfaces in the chromatographic system.