LC-MS/MS analysis of urinary benzodiazepines and Z-drugs

In this application note, explore a rapid and simplified solid phase extraction protocol and LC-MS/MS method for the analysis of urinary benzodiazepines and metabolites. Discover how the water wettable nature of Oasis® MCX Sorbent enables the elimination of the common conditioning and equilibration steps without any loss in recovery and reproducibility. This property of Oasis also enables the entire hydrolysis step to be conducted within the wells of the Oasis MCX μElution Plate, eliminating time-consuming and error-prone transfer steps, reducing the total number of post incubation steps from nine to five.