Reduction of Matrix Effects from Filter Effluents using Pall Acrodisc® MS Syringe Filters for LCMS Sample Preparation

This application note compares the cleanliness of the effluents from Pall’s Acrodisc MS syringe filters with two other commercially-available, alternative syringe filters from Competitor A (PVDF filter) and Competitor B (hydrophilic PTFE filter) by evaluating the ME due to potentially interfering extractable/leachable compounds in the LCMS analysis of three drug substances.