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Simultaneous Detection and Quantification of Δ9THC, 11-OH-Δ9THC and Δ9THC-COOH in Whole Blood by GC Tandem Quadrupole MS
14 Jun 2012A sensitive and reliable method for cannabinoids detection in human whole blood is presented here. The procedure involves extraction of a 1mL specimen acidified with 0.1mL of 10% acetic acid into hexane/ethyl acetate in the presence of deuterated standards. After evaporation, the drug and its metabolites were derivatized by methylation.