Aeris Core-Shell LC Columns for Proteins and Peptides
Core-Shell Particles Precision Engineered for Protein and Peptide Separations. Core-shell particle technology provides striking increases in peak capacity and resolution at lower backpressure, giving chromatographers the ability to achieve ultra-high performance on ANY system, HPLC or UHPLC. A uniform porous silica layer is grown around a solid, spherical silica core, providing effective retention and selectivi…
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Really useful column for peptide separation
Analysing protein samples with HPLC
We found the Aeris column very effective for analysis of our multi-peptide samples by HPLC. Really good separation of a fairly complex mixtures. The results were very robust and reproducible and the after sales care was also great, to help us optimise our experiments.
Review Date: 4 Sept 2023 | Phenomenex Inc
Biosimilars
Phenomenex Aeris widepore columns are very useful and robust columns for Biosimilars like monoclonal antibodies analysis and peptide analysis. These columns showed higher resolution than Agilent, ACE and Waters columns with very low pressure.
Review Date: 15 Jul 2015 | Phenomenex Inc
Separation of excipient compounds
This column works extremely well to separate large molecules for quantitation in pharmaceutical formulations. Phenomenex always has deals to get columns cheaper than the list price, however you will need to get in touch with your local Phenomenex sales rep.
Review Date: 18 Feb 2015 | Phenomenex Inc
Core-Shell Particles Precision Engineered for Protein and Peptide Separations.
Core-shell particle technology provides striking increases in peak capacity and resolution at lower backpressure, giving chromatographers the ability to achieve ultra-high performance on ANY system, HPLC or UHPLC.
A uniform porous silica layer is grown around a solid, spherical silica core, providing effective retention and selectivity with improved resolution, speed, and recovery. Next, optimizing the pore size and shell thickness for intact proteins or smaller peptide fragments provides well-defined depth penetration of biomolecules leading to maximum separation power.
Column Specifications:
- Phase: PEPTIDE XB-C18, WIDEPORE C4, WIDEPORE XB-C18, WIDEPORE XB-C8
- Particle Size: 1.7, 2.6, 3.6, 5.0 µm
- Pore Size: 200, 100 Å
- Length: 50, 100, 150, 250 mm
- ID: 2.1, 3.0, 4.6, 10.0, 21.2
PEPTIDE XB-C18
- Synthetic peptide impurity analysis
- Peptide mapping
- Identifying protein modifications
- Glycosylation
- Substitution
- Truncation - Analyzing post-translational modifications
- Deamidation
- Oxidation
- Deletions
WIDEPORE XB-C18
- Proteins
- Hydrophilic proteins
- PEGylated proteins
- High temperature separations
- Alternative selectivity for peptide mapping
WIDEPORE XB-C8
- Large proteins
- Moderately hydrophobic proteins
- Monoclonal antibodies
- Glycosylated proteins
- High temperature separations
WIDEPORE C4
- Very large proteins
- Very hydrophobic proteins
- Membrane proteins
- Least retentive
