Bioruptor® Pico
The Bioruptor® Pico is the new next-generation all-in-one shearing device, highly optimized for DNA shearing for next-generation sequencing, chromatin shearing for ChIP-seq applications, RNA shearing, protein extraction, and cell/tissue lysis. The Pico is the shearing device of choice for sequencing applications, providing optimal yields, lengths, and consistency and excels in shearing different fragment size ranges, which…
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Consistent sonication of DNA.
Sheering plasmid and genomic DNA
I used this product to sheer genomic DNA for NGS. I am very impressed by the reproducibility of results between samples and across experiments when conditions are maintained. I would recommend this product.
Review Date: 4 Dec 2020 | Diagenode
Reproducible results, easy to use and maintain.
Sample preparation
I used the Bioruptor Pico to prepare sonicated chromatin samples for ChIP assay. I have also used to sonicated DNA for MEDIP and MEDIP-seq. In addition, I use the Bioruptor Pico to sonicate protein lysates for WB and IP.
Review Date: 21 Mar 2020 | Diagenode
Amazing!
ChIP
Diagenode is a great company. We recently started using the Biorupter Pico in the lab and it's the best machine - so consistent and so user friendly. It's my lab child. I use the ChIP kits as well, and it's wonderful. All controls work, robust and really reproducible results.
Review Date: 30 Apr 2019 | Diagenode
Highly recommended biorupter.
Chromatin immunoprecipitation
The setup and instruction manual are easy to follow. With a 30s on 30s off for ten cycles I can obtain excellent shearing of my chromatin into 200bp fragments.
Review Date: 31 Oct 2018 | Diagenode
Stopped working within 6 Mo, horrible customer service.
Sonication of crosslink cell lysate
Poor customer service, make you jump though many hoops to prove their machine's are not working and even then wont believe their customers. The pico performance was never as good as they claimed and dropped of to nothing with in 6 months.
Review Date: 30 Jul 2018 | Diagenode
Good equipment and cannot get good results without it.
Chip assay
Easy to use. Consistently getting high quality results.
Review Date: 10 Apr 2017 | Diagenode
Excellent equipment and cannot get good results without it.
Chip on Chip assays
Easy to use. Able to obtain good quality samples with high efficiency. Highly recommend to other users
Review Date: 1 Mar 2017 | Diagenode
Best sonicator I've ever used.
Digest DNA for Chromatin Immunoprecipitation
Once setup the unit was easy to use and very reproducible. Once we got past the learning curve of setting up, the unit was the easiest I've ever used.
Review Date: 29 Jul 2016 | Diagenode
Consistent, reproducible results, even with a low number of cycles.
Sonicate DNA for library sequencing preparation
The Bioruptor Pico is a very well-manufactured piece of equipment and has so far worked flawlessly for sonicating DNA for library sequencing. It was very easy to un-package, setup, and run, and maintenance is also quite easy as long as you have a good source of lots of distilled water that is not de-ionized. Lastly, it is impressive that comparable results can be achieved with a lower number cycles than on Pico's larger sibling.
Review Date: 30 Jun 2016 | Diagenode
great results
ChIP-seq in tissues and cell lines
It is easy to use and saves more time while shearing DNA.
Review Date: 29 Jun 2016 | Diagenode
The Bioruptor® Pico is the new next-generation all-in-one shearing device, highly optimized for DNA shearing for next-generation sequencing, chromatin shearing for ChIP-seq applications, RNA shearing, protein extraction, and cell/tissue lysis.
The Pico is the shearing device of choice for sequencing applications, providing optimal yields, lengths, and consistency and excels in shearing different fragment size ranges, which are frequently required for downstream applications (e.g. bridge amplification) for sequencing. Moreover, the Pico provides flexibility in other applications saving the need to buy additional equipment. Unlike competing systems, the Pico has high throughput capabilities and can process up to 12 samples at once.
The only ultrasonicator you’ll ever need, optimized for:
- Next-Generation Sequencing (5 - 100 µl)
- Chromatin shearing (10 µl - 2 ml)
- RNA shearing
- Protein extraction
- Tissue and cell lysis
- Simultaneous sonication of 12 samples
- Small and light
