ChIP-exo High Resolution ChIP Assay
An optimized and streamlined protocol for high-resolution genome-wide mapping of transcription factor binding sites in the human and mouse genomes
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Active Motif's ChIP-exonuclease (ChIP-exo) Kit offers an optimized and streamlined protocol for high-resolution genome-wide mapping of transcription factor binding sites in the human and mouse genomes.
ChIP-exo is a modified ChIP-Seq approach that enables researchers to identify protein-DNA binding sites at a resolution of 20-95 base pairs, providing the ability to more precisely define DNA motifs and refine genome-wide protein / inding profiles for studies of mutational or SNP effects on transcription factor binding sites.
ChIP-exo Features:
- Identifies transcription factor binding sites at 20-95 bp resolution compared to traditional ChIP-Seq resolution of ≥200 bp
- Enables identification of unique transcription factor binding sites not revealed by ChIP-Seq
- Produces lower background and requires lower depth of coverage due to higher resolution of reads
- Requires less cells to produce comparable resolution as published methods (increasing cell numbers will increase the number of identified peaks)
- On-bead enzymatic reactions streamline sample processing
- Go from cells to sequence-ready library in a single assay
