Demecolcine
Demecolcine Synonyms: N-Deacetyl-N-methylcolchicine 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one N-Methyl-N-desacetylcolchicine Colchamine Santavy’s substance F CAS No.: 477-30-5 Molecular formula: C21H25NO5 Physical Appearance:Slightly yellow powder Purity: >98% (sum of enantiomers by HPLC) Soluble in: acidified water, alcohol, ether, chloroform Product Description: Used to immobilize chromosome…
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Demecolcine
Synonyms:
N-Deacetyl-N-methylcolchicine
6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one
N-Methyl-N-desacetylcolchicine
Colchamine
Santavy’s substance F
CAS No.:
477-30-5
Molecular formula:
C21H25NO5
Physical Appearance:
Slightly yellow powder
Purity:
>98% (sum of enantiomers by HPLC)
Soluble in:
acidified water, alcohol, ether, chloroform
Product Description:
Used to immobilize chromosomes by inactivating the spindle fiber mechanism during metaphase. Binds tubulin and interferes with microtubule-dependent cell functions. Demecolcine arrests cells in metaphase with no effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells.
Typical Application:
Used in cell celture medium at a final concentration of 0,4 ug/ml. Incubate cultures for 4-6 hours at 37°C. Remove medium containing demecolcine and replace with fresh medium.
