DU-145
Human Prostate Carcinoma cell line. Frozen cryovial. 1.5 Mio. cells/ml.
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Organism: Homo sapiens (human)
Ethnicity: Caucasian
Age: 69 years old
Gender: Male
Tissue: Prostate
Tumor: Carcinoma; from metastatic site: brain
Morphology: Epithelial
Growth Properties: Monolayer, adherent
Description: DU 145 was isolated by K.R. Stone et al from a lesion in the brain of a patient with metastatic carcinoma of the prostate and a 3 year history of lymphocytic leukemia. The line is not detectably hormone sensitive, is only weakly positive for acid phosphatase and isolated cells form colonies in soft agar. Ultrastructural analyses of both the cell line and original tumor revealed microvilli, tonofilaments and desmosomes, many mitochondria, well developed Golgi and heterogenous lysosomes. The cells do not express prostate antigen.
