Human Anti-TSHR Recombinant Antibody (clone K1-70)

Recombinant Human Antibody (K1-70) is capable of binding to TSH receptor (TSHR), expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TSH receptor (TSHR) mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TSH receptor (TSHR) proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The blocking autoantibody K1-70 binds more N-terminally on the TSHR concave surface than either the stimulating autoantibody M22 or the hormone TSH, and this may reflect its different functional activity. It is designed to support reliable, reproducible results in modern laboratories. It helps streamline your workflow, reduce troubleshooting, and deliver consistent performance across batches. Prominent attributes include productname and abbr.

Manufactured under rigorous quality controls, each lot is checked for key specifications to ensure lot‑to‑lot consistency. The format is optimized for ease of use and integration into existing protocols, with documentation available upon request.

Key Features / Benefits

• productname: Human Anti-TSHR Recombinant Antibody (clone K1-70)
• abbr: Anti-TSHR Antibody (clone K1-70)
• Target: TSHR
• Host Animal: Human
• Specificity: Human TSHR
• Immunogen: Human thyroid stimulating hormone receptor

Relevant Applications

• Block
• The TSHR antibody has been reported in applications of Blocking
• ELISA
• Inhibition
• Antagonist
• Blocking type human monoclonal autoantibody K1-70 was isolated from the same sample of patient peripheral blood lymphocytes as the thyroid stimulating monoclonal autoantibody K1-18.