One-Stop Antisense Oligonucleotide (ASO) Development Services
Integrated ASO development from sequence design and chemistry selection to preclinical PK/PD, safety, delivery (e.g., GalNAc), and CMC—supporting gapmer and steric-blocker approaches to advance programs efficiently toward IND.
One-Stop Antisense Oligonucleotide (ASO) Development Services
Receive your quote directly from the manufacturer.
Creative Biolabs offers an integrated ASO development pathway—from target assessment, sequence design, and chemistry selection to in vitro/in vivo pharmacology, safety assays, and CMC documentation—to shorten time to IND.
The platform supports gapmer and steric-blocker modalities, diverse backbones/sugars, delivery strategies (e.g., GalNAc), and developability analytics to enhance potency and translational success.
Key Features / Benefits
- End-to-end ASO workflow: design → screening → optimization → PK/PD/tox → CMC
- Modalities/backbones: gapmer, steric blocker; PS, mixed sugar chemistries
- Targeted delivery options (e.g., GalNAc) and tissue distribution studies
- IND-enabling documentation and regulatory support
Relevant Applications
- Target validation and lead optimization for genetic and hepatic indications
- In vitro/in vivo efficacy and safety packages for IND
- CMC readiness and method transfer for clinical manufacturing
