Hypersil Duet C18/SAX Columns
o Separate hydrophobic and ionic compounds in a single runo Select from two mixed mode phases, using either cation or anion exchange combined with C18o Retention of compounds is optimized using mobile phase pH, ionic strength and percent organic Product detail: Hypersil Duet columns are an ideal choice for unknown compounds and metabolism studies, as they can separate hydrophobic and ionic compounds in a single analysis r…
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o Separate hydrophobic and ionic compounds in a single run
o Select from two mixed mode phases, using either cation or anion exchange combined with C18
o Retention of compounds is optimized using mobile phase pH, ionic strength and percent organic
Product detail:
Hypersil Duet columns are an ideal choice for unknown compounds and metabolism studies, as they can separate hydrophobic and ionic compounds in a single analysis run. Retention of ionizable species is manipulated by adjustment of the mobile phase pH, and retention of hydrophobic compounds is control by a solvent gradient.
Duet SAX/C18 is a mixed-mode phase with 50% hydrophobic stationary phase (C18) and 50% strong ion anoin exchanger. This stationary phase makes expensive and time-consuming procedures such as column switching, using ion pair reagents or using columns in series redundant.
The main application areas of Hypersil Duet lie in metabolism studies, where the main component has strong hydrophobic character but the metabolites contain ionic groups.
