iLite® CD3 effector cell/ T-Cell activation Bioassays
The iLite® CD3 Effector Cell line is a reporter gene cell line that offers a convenient and powerful way of measuring the efficacy antibodies have to elicit T cell activation through CD3 interactions.
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In recent years, a variety of immunotherapy strategies aimed at inducing, strengthening, and/or engineering T cell responses have emerged as promising approaches for the treatment of diseases such as cancer and autoimmunity. With the iLite CD3 Effector cell - a cleverly engineered effector cell that closely resembles the natural engagement of the TCR/CD3 complex, and homologous target cells with a controlled antigen expression (+) or depletion (-), this can be assessed with a robust assay. The iLite T-Cell Activation Bioassays is a dual cell system based on bioluminescent cell-based assays. The portfolio consists of cell lines provided in an “assay-ready” format for a rapid and convenient workflow and a further reduction in assay variability and can be used for the discovery and development of novel biologics such as bispecific antibodies and CAR-T cell therapies.
