MicroCal PEAQ-DSC Automated
Gold standard protein stability analysis for the regulated environment
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Great and very reliable machine for antibody formulation screening
Melting onset for Biologics
The results obtained with the machine are reliable, accurate and reproducible. Sample loading is easier with easy to moderate complex of data analysis.
Review Date: 10 May 2024 | Malvern Panalytical
Great instrument
Antibody thermal stability
MicroCal DSC is a very useful instrument for determining Tms of antibodies for selecting drug candidates and evaluating developability. It's easy to use and the data are very reproducible. The instrument is also easy to maintain and very reliable.
Review Date: 15 Dec 2021 | Malvern Panalytical
Manufacturer's Response
Thank you for the feedback. We are glad you like the ease of use and data reproducibility, good to hear that the DSC is making an impact in your work in selecting drug candidates.
The MicroCal PEAQ-DSC Automated system delivers high throughput, highly sensitive protein stability analysis with low sample consumption, in an automated, integrated platform for increased productivity. All cell filling and cleaning functions are fully automated for walk-away operation.
Data generated by the MicroCal PEAQ-DSC Automated provide critical guidance for biopharmaceutical development in protein engineering, (pre)formulation development, process development, manufacturing change control and biosimilarity and biocomparability studies. Unattended operation enables 24-hour screening, while the integrated software streamlines workflows, facilitates non-subjective data analysis, performance qualification and compliance with 21 CFR Part 11 and Annex 11 regulations, all delivering high integrity data and driving productivity in biopharmaceutical research.
Key Features:
- Gold standard stability-indicating technique requiring minimal assay development
- Direct and label-free measurement of biomolecular native-state stability in solution
- Standard 96-well plate format for high capacity and easy loading, with thermostatically-controlled storage of up to 6 plates
- Fully integrated autosampler enables unattended analysis of up to 50 samples per day
- Automated cell filling and cell cleaning functions permit unattended operation
- Measurement of very tight binding constants, up to 1020M-1
- Powerful MicroCal PEAQ-DSC software minimizes typical data analysis time and includes:
- PEAQ-Compliance: The system is available with Malvern Panalytical Access Controller (MAC) to limit access to user-defined SOPs and data analysis features. Data can be displayed using the Report Generator with user details and the ability to sign using electronic signatures to facilitate the integration of the workflow into your company’s quality system and aid compliance with 21 CFR Part 11 and Annex 11 regulations. This is provided as an optional accessory
- PEAQ-Performance: Automatically detects and validates system readiness for optimal performance
- PEAQ-Smart (including PEAQ-Finder): For SOP-based operation and data analysis. Provides new algorithms to detect even subtle peaks and shoulders, facilitating the automatic, non-subjective identification of multiple transitions, such as those seen in multi-domain proteins
- PEAQ-Compare: For the quantitative comparison of DSC traces for comparability studies, ideal for batch-to-batch and biosimilarity studies
- Network-ready: email updates sent during the analysis to keep you informed of assay progress
