microOptilab™ Refractive Index Detector for UHPLC
Universal detection for UHPLC and µSEC-MALS.
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Ease of use
Sample Analysis
Great detector
Review Date: 13 May 2024 | Waters | Wyatt Technology
Amazing instrument, critical to Analytical chemistry!
MW determination of monoclonal antibodies
The product is amazing and provides detailed analytical demonstration that is critical to analytical chemistry in a biopharmaceutical environment. It is a reliable source of information that delivers excellent and consistent results. The software and instrument are easy to use and always provide the best results.
Review Date: 23 Jun 2016 | Waters | Wyatt Technology
The microOptilab™ differential refractive index (dRI) detector is specifically designed for use with any UHPLC system. It works alone as a universal concentration detector, or in combination with the µDAWN™multi-angle light scattering (MALS) detector to measure absolute molar mass and size of macromolecules and nanoparticles in solution, via µSEC-MALS.
Considering the extremely small peak volumes of UHPLC, band broadening in the microOptilab™ is kept to the absolute minimum, at less than 4 µL, as compared to 20-40 µL or more from other dRI detectors.
Features:
- dRI noise: 1.5x10-9 RIU
- dRI range: ±4.7x10-3 RIU
- Dynamic range: 6,000,000:1
- Absolute RI sensitivity: ±0.002 RIU
- Absolute RI range: 1.2 – 1.8 RIU
- Temperature control: heated/cooled 4 - 65°C, including active stabilization—even at room temperature
- Wavelength: 660 nm, matched to the µDAWN™; other wavelengths available
- Touch-panel display for immediate access to data, diagnostics and settings
Applications:
- Universal online concentration measurement for chromatography, especially µSEC-MALS for absolute molecular weight
- Analysis of conjugated proteins, co-polymers and nanoparticle-encapsulated drugs/proteins/DNA/RNA when combined with a MALS and UV detector
