Nuance™

Multi-label imaging without cross-talk

As biological imaging becomes more about studying complex systems rather than single events, Nuance multispectral imaging systems let you quantitate multiple molecular markers even when they are co-localized in a single tissue section, producing clear and accurate images of each individual label on a multi-label tissue section.

TRIO is the newest addition to CRi’s award-winning Nuance multispectral imaging (MSI) product family and is the most affordable of CRi’s systems. Its compact design and intuitive software make it an easy add-on to any microscope with a camera port. No advanced knowledge of multispectral imaging is required. Setup and operation are literally accomplished in minutes.

TRIO enables simple image capture and high-contrast separation of any three chromogens or any three fluorophores in its spectral ranges. Additionally, autofluorescence is removed, increasing signal-to-noise by up to 100x and vastly improving quantitation. It can take both high-resolution color as well as multispectral images, and automatically exports images in standard image file formats.

Download and view our video clips to learn more about how Nuance captures, unmixes and quantitates. Nuance systems are compatible with Molecular Devices' MetaMorph™. Nuance systems deliver flow-cytometry-like data while preserving the morphological context down to the sub-cellular level.

• Biomarker discovery
  
• Signaling pathways
  
• Tumor microenvironment
  
• Nuclear, cytoplasmic, membrane measurements in each cellular compartment