Products & ReviewLife Sciences
Reconstructed Bone (r-Bone™) 3D Cell Culture Service, Mulitiple Myeloma
zPREDICTAAvailable: Worldwide
Human, bone marrow 3D culture model enabling accurate testing of therapeutic agents against multiple myeloma.
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Reconstructed Bone (r-Bone) platform offers 1-to-1 reconstruction of cellular and extracellular compartments of the human bone marrow microenvironment. r-Bone preserves the architecture of human bone marrow and enables accurate evaluation of response to treatment.
Unique Advantages:
- Clinically relevant system demonstrating high correlation with clinical outcomes (in a clinical study, 19 out 21 cases of response vs. resistance to treatment were predicted correctly).
- Supports evaluation of efficacy and toxicity in a single assay.
- Suitable for testing of immuno-oncology agents.
- Comprehensive system to ascertain mechanisms of drug resistance.
Features:
- Bone marrow-specific extracellular matrix (ECM) drives native organization of primary multiple myeloma cells ex vivo.
- Multiple myeloma medium supplement enables reconstruction of a disease-specific mileu.
- Long-term survival of primary patient cells (viability is maintained for >30 days as compared to 1-4 days in standard 2D culture or Matrigel).
- Maintains cellular heterogeneity of the primary human bone marrow.
- Suitable for evaluation of single agents and combination treatments.
- Compatible with multiple therapeutic modalities, e.g. small molecules, antibody-drug conjugates (ADC), immuno-oncology agents, including CAR-T cells.
- Compatible with standard readouts, such as FACs, imaging, bioassays, etc.
