Life Sciences Products & Reviews

Novabiochem® building blocks for routine peptide synthesis applications

Pseudoproline dipeptides are undoubtedly the most powerful tools described to date for enhancing synthetic efficiency in Fmoc SPPS. Novabiochem® now offers 28 pseudoproline dipeptides - representing the widest selection on the market today The routine use of pseudoproline dipeptides has been found to: Avoid costly and unnecessary repeat syntheses of failed sequences Increase purity of crude products Simplify HPLC puri…

Two new additions to the SNAP CAP™ range. These caps are pre-cut to avoid any vacuum generation problems.

Calbiochem® supplies a wide variety of products for the study of apoptosis, includingActivators and Inhibitors Antibodies and Blocking Peptides Assay Kits Caspase-related products Mitochondrial Permeability-Transition Reagents and Related Products Poly(ADP-Ribose) Glycohydrolase (PARG) Inhibitors Poly(ADP-Ribose) Polymerase (PARP) Inhibitors Telomerase Products View the online interactive pathways to easily locate the product…

The pET System is the most powerful system yet developed for the cloning and expression of recombinant proteins in E. coli. Based on the T7 promoter-driven system, Novagen’s pET System has been used to express thousands of different proteins. pET Vectors are supplied as purified plasmid DNA (10 µg) plus an Induction Control strain (supplied as a glycerol stock). Complete sequences and detailed vector maps are available.

The D-Tube™ Dialyzers can be used for dialysis and electroelution of proteins or nucleic acids from polyacrylamide or agarose gels. The disposable, single-use tubes require no syringes, microcentrifuges, or laborious steps to manipulate small samples volumes. The sample is added and removed using a standard laboratory pipette. Available with molecular weight cut-offs from 3.5 to 14 kDa, the D-Tube Dialyzers are designed in thr…

May be used in a variety of laboratory assays Flat bottom strips are designed to easily break apart and may be used in an style strip holder that allows each individual well to be positioned back into the plate once broken High binding surface binds medium (>10kD) and large biomolecules that possess ionic groups and/or hydrophobic regions. Binding capacity is approximately 400 to 500ng IgG/cm2. Ideal for immunoassays Reco…

Morphology Explorer V2 is a powerful general-purpose image analysis application for measuring size, shape, and distribution of cells, colonies, and subcellular components.  It performs sophisticated calculations in a turn-key, automated manner allowing higher throughput of complex cell-based assays.  This application has been biologically validated, enhancing confidence in your image-based data.    Available for the Cellomics…

Cell Health Profiling V2 is a flexible image analysis application employing advanced cell-level logic to detect and classify cell health-related events.  It analyzes patterns of cellular fluorescent labeling that can be used to classify cells as undergoing apoptotic, necrotic, or other cell death mechanisms.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for the Cel…

The Cell Cycle V2 BioApplication is a sophisticated image analysis algorithm that performs automated analysis of the cell cycle phase of individual and populations of cells.  It reports cell cycle phase as well as the state of up to 3 target proteins for every cell analyzed, and correlates the target data with DNA content.  This application has been biologically validated, enhancing confidence in your image-based data.  Availa…

The Cytotoxicity V2 BioApplication is an image analysis application that simultaneously measures four markers of cytotoxicity (nuclear fragmentation/condensation, permeability, lysosomal mass-pH, and cell count) and reports individual and composite indicies of cytotoxicity.  The V2 version has been enhanced with object segmentation to allow clumped cells to be efficiently analyzed.  Available for the Cellomics ArrayScan VTI, A…

Extended Neurite Outgrowth V2 is an advanced image analysis algorithm that can quantitate neurite outgrowth with features such as cell body area and branch point quantitation, cell subpopulation analysis, Ability to analyze neuron subsets expressing up to two distinct neurotransmitters.  It reports all features at the cell, well, and subpoulation level, and is biologically validated to enhance confidence in your image-based da…

Compartmental Analysis V2 is a powerful general image analysis tool for quantitating intracellular intensity changes in specific sub-cellular regions across multiple fluorescent channels.  It performs spot analysis and reports intensity ratios and differences among sub-cellular regions and/or different fluorophores.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for…

The Cell Motility V2 BioApplication is a advanced image analysis algorithm for measuring the overall motility of cells.  It quantitates total distance traveled by each cell exposed to growth factor or compound for a quantiative assessment of cell motility.  The V2 version includes advanced analytical capabilities such as population analysis and object segmentation.  This application has been biologically validated, enhancing c…

Spot Detector V2 performs measurements of number, size, and other features of spots in cells.  It is an easy-to-use and essential component of any image analysis software suite.  This tool is excellent for measuring receptor internalization and trafficking, cell proliferation and counting, Analyzing populations. This application has been biologically validated, enhancing confidence in your image-based data.  Available for the…

The Neurite Outgrowth V2 BioApplication is a streamlined image analysis algorithm for morphological analysis of neurite outgrowth. Utilizes fluorescent images of neurons and neurites stained for tubulin to quantitate the number and length of neurites in a population of cells.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for the Cellomics ArrayScan VTI, ArrayScan x…

Cyto-Cell Membrane Translocation V2 is a multi-channel image analysis algorithm for analysis of targets that translocate from cytoplasm to cell membrane.  It utilizes colocalization of fluorescent markers to report whether the target is co-localized to the membrane, and reports cells' behavior relative to a control population.   This application has been biologically validated, enhancing confidence in your image-based data.  A…

GPCR Signaling V2 is a high-content image analysis application for quantitation of the activation of G-protein coupled receptors.  Classifies cells into different phases based on pattern of receptor complex distribution and reports details of and percentage of cells with Type A and Type B recycling activity.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for the Cel…

The Multiparameter Apoptosis Kit comprises three spectrally distinct fluorophores that label cellular targets to allow assessment of cell health by looking at several biological parameters.  This kit specifically labels nuclei, f-actin, and mitochondrial mass/potential in cells.  The kit has been validated for use on Cellomics’ ArrayScan® HCS Reader but may be applied to any imaging system.  Available in Evaluation Size (Five…

The Multiparameter Cytotoxicity 1 Kit  comprises three spectrally distinct fluorophores that label cellular targets to allow assessment of cell health by looking at several biological parameters.  This kit contains indicators for nuclei, permeabilized cells, and lysosome mass/pH.  The kit has been validated for use on Cellomics’ ArrayScan® HCS Reader but may be applied to any imaging system.  Available in Evaluation Size (Five…

Neuroscreen-1 is a neuronal-like cell line optimized for screening.  It is a subclone of PC12, a widely used cell line derived from rat pheochromocytoma cells that serves as a standard model system for neurons.  Neuroscreen-1 cells display several substantial advantages over PC12 cells, including 50-80% faster growth, no tendency toward cell aggregation, high and accelerated responsiveness to NGF (measurable neurites within 2…

HPLC Valves

MIAS-2 readers are a new generation of HTS microscopy readers with an unequaled blend of sensitivity, flexibility and speed.  They are designed to cover the throughput and flexibility needs at multiple phases across the R&D value chain.  In drug discovery R&D, applications include target identification, target validation, assay development, high throughput screening, hit-to-lead, deep pharmacology and ADMET.  Unique features…

What is it?  When you plan to access our technology platform, we will assist you in validating  your assay technology  in our platform technology.  Pending on your needs, we will accept your images, your plates with samples or we will create samples according to your protocols.