Immunohistochemistry Products & Reviews

Heat Aggregated Gamma Globulin acts as a potent classical complement pathway activator, functioning similarly to naturally occurring immune complexes. When activated by a potent activator, such as Quidel’s Complement Activator, nearly all of the C4 in a given complement source may be converted into cleavage products.

Tumors characterized as "hot" exhibit signs of inflammation, high T cell infiltration, and expression of PD-L1. These inflamed tumors typically respond well to checkpoint inhibitor immunotherapy. PhenoCode Signature Immuno-Contexture panel (CD8, CD68, PD-L1, FoxP3, PanCK) enables profiling of the tumor microenvironment for CD8+ T lymphocytes and PD-L1 expression. Map additional phenotypes by adding a 6th marker to the panel fr…

The composition of immune cells within the tumor microenvironment, such as T cells, B cells, and macrophages, varies between tumors and is strongly associated with outcomes to combination therapies. PhenoCode Signature Immune Profile panel enables profiling of the tumor microenvironment using 4 key immune cell markers (CD8, CD68, CD3e, CD20) and a tumor marker (PanCK). Map additional phenotypes by adding a 6th marker to the pa…

The ability to determine whether tumor cells are proliferating and T cells are activated could provide important information about the anti-tumor response and be an indicator of prognosis. PhenoCode Signature Activated TIL Status panel (CD8, CD3e, Ki67, Granzyme B, PanCK) enables determination of Ki67 positivity in addition to profiling of the tumor microenvironment for CD8+ T lymphocytes that are activated. Map additional phe…

Tumor associated macrophages (TAMs) play a key role in regulating the inflammatory or immunosuppressive state of the tumor microenvironemnt (TME). Distinguish between M1 (pro-inflammatory) and M2 (anti-inflammatory) TAMs using the PhenoCode™ Signature M1/M2 Polarization panel (CD8, CD68, CD163, PD-1, PD-L1) to evaluate polarization profiles in the TME. Map additional phenotypes by adding a 6th marker to the panel from the anti…

As the major population of immune cells within the tumor microenvironment (TME), T cells are a driver of anti-tumor immunity. T cell exhaustion and the presence of immunosuppressive cells can contribute to an immunosuppressive TME. PhenoCode™ Signature T Cell Status Panel (CD8, CD4, CD20, FoxP3, PD-1) allows for identification of distinct T Cell subsets and effector functionality status. Map additional phenotypes by adding a 6…

Immunoassays, Reagents and Controls

PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of PD-L1 protein in certain types of formalin-fixed, paraffin-embedded (FFPE) cancer tissues using EnVision FLEX visualization system on Autostainer Link 48.

ISH and IHC Automation for Whole Mounts and Slides

Monoclonal Anti-Claudin-18.2 Antibody, Mouse IgG1 (3B10) was developed to be exquisitely CLDN18.2 specific, characterized as not cross-reacting with CLDN18.1 and without background staining.