Preclinical Safety, Biodistribution, and Tumor Infiltration Analysis of CAR-T Cell Targets Using in situ Hybridization Technology

Chimeric antigen receptor (CAR) T cell therapy has proven to be highly effective in treating hematologic malignancies, and major efforts are being made to achieve similar efficacy in solid tumors. This poster evaluates a method for tracking and monitoring CAR+ T cells within the context of intact tissue and tumor to understand the mechanisms underlying off-tumor toxicity and efficacy in tumor killing.