ADME-Toxicology Products & Reviews

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ADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Annexin V : FITC Apoptosis Detection Kit I

BD Biosciences

Apoptosis is a normal physiologic process which occurs during embryonic development as well as in maintenence of tissue homeostasis. The apoptotic program is characterized by certain morphologic features, including loss of plasma membrane asymmetry and attachment, condensation of the cytoplasm and nucleus, and internucleosomal cleavage of DNA. Loss of plasma membrane is one of the earliest features. In apoptotic cells, the mem…

4.5/5.0
|2 Reviews
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The PhysioMimix™ OOC Range of Single and Multi-organ Microphysiological Systems (MPS) by CN Bio

CN Bio

PhysioMimix™ microphysiological systems generate in vitro microtissues that mimic the structure and function of human tissues and organs. Through the simulation of human biological conditions, they bridge the gap between traditional cell culture and human studies, reliably predicting drug effects to facilitate the accelerated development of safe and efficacious therapeutics. 

4.9/5.0
|3 Reviews
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ApoTox-Glo™ Triplex Assay

Promega Corp.

The ApoTox-Glo™ Triplex Assay combines three assay chemistries to easily assess viability, cytotoxicity and apoptosis events in the same cell-based assay well. First, viability and cytotoxicity are determined by measuring two differential protease biomarkers simultaneously with the addition of a single nonlytic reagent containing two peptide substrates. The live-cell protease activity is restricted to intact viable cells and i…

4.6/5.0
|3 Reviews
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Griess Reagent System

Promega Corp.

The Griess Reagent System measures nitrite (NO2–), which is one of two primary stable and nonvolatile breakdown products of nitric oxide (NO). Nitric oxide is an important physiological messenger and effector molecule in many biological systems, including immunological, neuronal and cardiovascular tissues. This assay relies on a diazotization reaction that was originally described by Griess in 1879. Through the years, many mod…

4.7/5.0
|1 Review
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ROS-Glo™ H2O2 Assay

Promega Corp.

The ROS-Glo™ H2O2 Assay is a homogeneous, fast and sensitive bioluminescent assay that measures the level of hydrogen peroxide (H2O2), a reactive oxygen species (ROS), directly in cell culture or in defined enzyme reactions.   This assay allows identification of conditions or test compounds, such as small molecule inhibitors or inducers, that alter ROS levels. The scalable multiwell format couples a stable luminescent si…

5.0/5.0
|2 Reviews
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CellTiter-Glo® Luminescent Cell Viability Assay

Promega Corp.

The CellTiter-Glo® Luminescent Cell Viability Assay(a,b) is a homogeneous method of determining the number of viable cells in culture based on quantitation of the ATP present, an indicator of metabolically active cells. The CellTiter-Glo® Assay is designed for use with multiwell formats, making it ideal for automated high-throughput screening (HTS), cell proliferation and cytotoxicity assays. The homogeneous assay procedure in…

4.7/5.0
|22 Reviews
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CellTiter-Glo® 2.0 Assay

Promega Corp.

The CellTiter-Glo® 2.0 Assay provides a homogeneous method for determining the number of viable cells in culture by measuring the amount of ATP present, which indicates the presence of metabolically active cells. The CellTiter-Glo® 2.0 Assay is based on the original CellTiter-Glo® Assay chemistry but with improved storage convenience for easy implementation. The CellTiter-Glo® 2.0 Assay is provided as a single, ready-to-use re…

4.9/5.0
|2 Reviews
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Lactate-Glo® Assay

Promega Corp.

The Lactate-Glo™ Assay is a bioluminescent assay for rapid, selective and sensitive detection of L-lactate in biological samples. Lactate is produced by glycolysis, a major metabolic pathway responsible for glucose homeostasis and energy production (1,2). Once considered merely a byproduct of glycolysis, lactate is now considered an important regulatory molecule of intermediate metabolism involved in cancer development, diabet…

5.0/5.0
|1 Review
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Digitonin

Promega Corp.

Digitonin can be used in cell viability and cytotoxicity assays. It is a detergent solution useful for permeabilizing cells and for creating a cytotoxicity chemistry positive control. Supplied at 20mg/ml in DMSO

5.0/5.0
|1 Review
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CellTiter 96® AQueous One Solution Cell Proliferation Assay (MTS)

Promega Corp.

The CellTiter 96® AQueous One Solution Cell Proliferation Assay is a colorimetric method for determining the number of viable cells in proliferation, cytotoxicity or chemosensitivity assays. The CellTiter 96® AQueous One Solution Reagent contains a tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt; MTS(a)] and an electron coupling reagent (phenazine ethos…

5.0/5.0
|2 Reviews
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GSH-Glo™ Glutathione Assay

Promega Corp.

The GSH-Glo™ Glutathione Assay is a luminescence-based assay for the detection and quantification of glutathione (GSH). The assay is based on the conversion of a luciferin derivative into luciferin in the presence of glutathione, catalyzed by glutathione S-transferase (GST). The signal generated in a coupled reaction with firefly luciferase is proportional to the amount of glutathione present in the sample. Luminescence is gen…

5.0/5.0
|3 Reviews
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EVE Plus - One of the Fastest Cell Counters

NanoEntek

EVE™ Plus, one of the world’s fastest automated cell counters, is designed to measure cell count and viability with accuracy and precision by using the standard trypan blue technique within 1 second. EVE™ Plus also identifies and counts clumpy cells as several individual cells for accurate analysis.

4.8/5.0
|49 Reviews
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Glucose-6-Phosphate Dehydrogenase Activity Assay Kit

BioVision Inc

Kit Summary: • Detection method- Absorbance (450 nm) • Sample type- Cell and Tissue culture supernatants, urine, plasma and serum, as well as many other biological fluids etc. • Species reactivity- Mammalian • Application- The G6PDH Assay Kit can detect as low as 0.04mU G6PDH per well. Features & Benefits: • Simple procedure; takes ~ 30-60 minutes • Fast and convenient Kit components: • G6PDH Assay Buffer • G6PDH Substrate • G…

4.5/5.0
|2 Reviews