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AAV capsid protein and particle antibodies

Name: AAV capsid protein and particle antibodies
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Adeno-associated virus antibodies for comprehensive monitoring of different stages of AAV vector production.

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Achieve high quality vector preparation while ensuring process consistency and standardization.

Adeno-associated virus (AAV) derived vectors entail several advantages for viral based gene therapy, amongst others AAV is known to be non-pathogenic. The absence of any symptoms or human disease being associated with AAVs makes AAV derived vectors a perfect vehicle for the delivery of genetic material to human cells. In addition, AAV possesses very low cytotoxicity and low immunogenicity. Therefore, AAV vectors are suitable for in vivo gene delivery.

AAV antibodies are useful for the comprehensive monitoring of different stages of AAV vector production. There are two main categories of AAV antibodies that are suitable for the validation of different steps during the production process:

AAV capsid protein antibodies that specifically react with denatured AAV capsid proteins and thereby recognize the linear epitopes of the viral capsids
AAV particle antibodies that specifically react with intact AAV particles, i.e. empty and full capsids and thereby recognize a conformational epitope of the assembled capsids of certain serotypes

PROGEN offers a range of AAV capsid protein antibodies and AAV particle antibodies for comprehensive monitoring of vector manufacturing, including the following: