Hydrocortisone
Enhances proliferation and differentiation of endothelial, epithelial, mesenchymal, and oligodendrocyte cells
Hydrocortisone
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Great Customer service and technical team's professional response.
Cell Culture
The product Hydrocortisone we purchased, we were also confirming with the technical team on the concentration calculations that is required for cell culturing. The Merck technical team was amazing in the speed of reply and professionalism.
Review Date: 11 Feb 2022 | STEMCELL Technologies Inc.
Hydrocortisone is a glucocorticoid hormone with anti-inflammatory and immunosuppressive effects (Kang et al.; Langhoff & Ladefoged). It is also commonly used as a supplement for endothelial, epithelial, mesenchymal, or oligodendrocyte cell culture media, as it supports growth and differentiation. This product is supplied as the sodium salt of hydrocortisone 21-hemisuccinate, which is a more water-soluble form of hydrocortisone.
Hydrocortisone is required as a supplement in MyeloCult™ H5100 (Human; Catalog #05100) and MyeloCult™ M5300 (Mouse; Catalog #05300), for long-term cultures and the long-term culture-initiating cell (LTC-IC) assay. For complete instructions, refer to the Technical Manual for Human (Document #28412) or Mouse (Document #28417) LTC-IC Assays, available at www.stemcell.com or contact us to request a copy.
MAINTENANCE AND SELF-RENEWAL
- Enhances proliferation and self-renewal of limbal stem cells in explant cultures (Yu et al.).
- Supports long-term growth of immature human myeloid cells in culture (Salahuddin et al.).
- Increases the activity of glucose 6-phosphate dehydrogenase in mouse mammary epithelial cells in culture in the presence of insulin (Oka & Perry).
DIFFERENTIATION
- With ATRA, EGF, KGF, and HGF, promotes epithelial differentiation of adipose-derived stem cells (Li et al.).
- Promotes differentiation of mouse embryonic stem (ES) cell-derived definitive endoderm toward lung alveolar epithelial cells (Mokhber Dezfouli et al.).
IMMUNOLOGY
- Inhibits the bioactivity of the proinflammatory cytokine interleukin 6 (IC₅₀ = 6.7 mM; Kang et al.).
- Suppresses the activity on phytohemagglutinin (PHA)-stimulated lymphocytes in vitro (Langhoff & Ladefoged).
