Drug Discovery & Development Products & Reviews

From small-scale R&D to large-scale manufacturing, Pion homogenizers deliver exceptional fluid processing for particle size reduction (micronization,) cell disruption, and the creation of stable micro- and nanoemulsions and dispersions. Built for scalability, we make the transition from lab to commercial production seamless. Trusted by pharmaceutical, biotech, cannabis, chemical, and food and beverage manufacturers worldwide.

Achieve ultra-high RNA yields with MEGAscript™ kits—ideal for in vitro or in vivo translation studies needing unlabeled or low specific activity RNA.

Discover a world of possibilities with Invitrogen Vivofectamine Delivery Solutions. Rationally designed for in vivo delivery of nucleic acid vaccines and therapeutics, Vivofectamine products and services offer you a distinct edge in basic research and therapeutic development with LNP technology.

Simplify synthesis and scale-up of potent mRNA with third-generation CleanCap®—proven technology for enhanced in vivo translatability.

Assay (GC): ≥ 99.0%

Biotage® VacMaster™ Sample Processing Manifolds allow samples to be processed simultaneously under vacuum. Easy-to-use vacuum controls provide excellent sample flow control, leading to reproducible, reliable extraction conditions.

Lyse or homogenize the toughest samples in seconds. Biotage® Lysera is an advanced, easy-to-use bead mill homogenizer designed for rapid, efficient grinding, lysing, and homogenizing of diverse biological samples. With a compact front-loading design, 99 programmable settings, temperature monitoring, and a wide range of accessories, it delivers reproducible results for any sample type without downtime between runs.

Biotage® Extrahera™ Peptide automates sample workup with precision and ease. Designed for synthetic labs, it enables automated solid phase extraction (SPE) and catch-and-release purification of up to 96 samples simultaneously. Positive pressure processing and complementary consumables ensure consistent, high-purity peptide samples free of catalysts and excess reagents.

EVOLUTE® Sample Preparation products feature advanced water-wettable polymer-based sorbents that deliver clean extracts and consistent analyte recovery for accurate LC-MS/MS quantification. Designed to minimize ion suppression and matrix effects, they provide reliable performance across a wide range of acidic, basic, and neutral compounds.

Biotage® PeptiPEC-96 High Throughput Kits streamline peptide purification with the automated PurePep® Easy Clean (PEC™) catch-and-release strategy. Purify 96 peptides simultaneously while removing impurities efficiently for cleaner, higher-quality peptide libraries.

Biotage® PeptiRen-96 well plates streamline peptide library workflows by enabling simultaneous post-synthesis clean-up of 96 crude peptides. Featuring reversed-phase media optimized for peptide SPE, they provide an efficient, automatable solution for rapid enrichment and preliminary screening.

The Biotage® Sfär family of flash chromatography columns simplifies purification, increases loading capacity, and delivers purer fractions.

Rapidly synthesize high-quality peptides with microwave-assisted chemistry—enhancing yield, reducing cycle times, and lowering reagent costs using a compact, versatile workstation.

wavePREP is an efficient, rapid, and safe tool for the post-processing step in the oligos production. Its process combines cleavage and deprotection into a single step, ensuring both a superior workflow and product yields by removing the evaporation phase.

The Milestone synthWAVE is designed for safe, reliable and reproducible scale-up of microwave enhanced chemical reactions. The synthWAVE is capable of higher temperature and pressure than any other microwave reactors. Milestone synthWAVE features the unmatched Single Reaction Chamber (SRC) patented technology that ensures scale, reaction screening, highest temperature and pressure. It is able to handle single or multiple react…

The new Milestone flexiWAVE overcomes the limitation of conventional microwave synthesis reactors, as it consists of a single microwave platform that, in combination with specific accessories, allows the chemists to perform classic glassware and high pressure synthesis, as well as solid-phase reactions.

The AptaFluor® SAH Methyltransferase Assay Kit enables ultra-sensitive, direct detection of SAH—the universal product of methyltransferase reactions—using a riboswitch-based TR-FRET format. With no coupling enzymes required, it delivers high signal-to-background, Z’ ≥ 0.7, and is fully HTS-compatible for drug discovery and inhibitor screening.

BellBrook Labs’ Lead Discovery Services deliver expert support for hit-to-lead efforts. From inhibitor screening and potency profiling to residence-time, mechanism-of-action, and selectivity studies, their team tailors efficient enzymatic assays to your program—accelerating lead advancement with precision and flexibility.

The Transcreener® cGAMP cGAS Assay Kit offers mix-and-read fluorescent detection of cGAMP—the product of cGAS activity—with no coupling enzymes required. Available in FP or TR‑FRET readouts (far-red tracers minimize interference), it’s HTS-ready (Z’ ≥ 0.7), automation-compatible, and validated on 96‑, 384‑, and 1536‑well formats for enzyme kinetics, SAR, and inhibitor screening.

The CD73 activity assay for HTS and hit-to-lead. Measure specific activity of CD73 in a simple mix-and-read format. The kit is designed for compound library screening and follow-up inhibitor discovery.

The Transcreener dAMP Exonuclease Assay directly measures dAMP produced by exonuclease enzymes as they cleave polynucleotides. 

The Transcreener® GDP GTPase Assay Kit directly measures GDP produced during GTP hydrolysis in a homogeneous mix‑and‑read format—no coupling enzymes needed. Compatible with GTPases, GAPs, and GEFs, it supports FP, FI, and TR‑FRET readouts using far‑red tracers to reduce interference. HTS‑ready with excellent sensitivity (Z′ ≥ 0.7), it streamlines screening and profiling workflows.

Express proteins—even large and challenging constructs—and conduct screening studies directly in HEK293 cells using efficient, reliable TARGATT™ large knock-in technology. With the ability to efficiently and site-specifically insert 20+ kb of DNA (more with nested reactions) into the reliable H11 safe harbor site, TARGATT™ HEK293 kits move you to the next inflection point faster.