Drug discovery > Target Discovery Products & Reviews

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Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.

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CryoFile™ Freezer Boxes

WHEATON

Wheaton CryoFile™ and CryoFile XL™ cryogenic vial freezer boxes offer secure storage for high value samples when immersed at 196oC. The new design provides compartments numbered from 1-81 which aids in identifying the contents of the box without the need to check the vials. The numbered grid on the inside lid provides a space for written identification.The bottom of the box uses the same numbering system. Partitions are remova…

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Cryule® Vials

WHEATON

Wheaton cryogenic vials, caps, vial racks, and freezer boxes are designed for simple identification and effortless handling. With Wheaton plastic Cryules®, both the closures and tubes are manufactured from medical-grade polypropylene with the same coefficient of expansion; this further enhances the leak proof qualities of these vials at changing temperatures.All Wheaton Cryules and racks are autoclavable up to 121°C. When auto…

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BI-3000G: Ultra-sensitive SPR Instrument with Built-in Versatility

With BI-DirectFlowTM flow injection technology and Gas Phase SPR, compatible with Electrochemistry SPR The BI-3000G SPR instrument is equipped for both liquid and vapor phase SPR analyses, and utilizes a unique detection technology that delivers high sensitivity (< 10-5 degrees) and fast response times (< 0.5 ms) with superior flexibility. The innovative use of interchangeable analysis modules is specially developed to fulfill…

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BI-2000: Ultra Sensitive SPR Instrument

High Performance Surface Plasmon Resonance (SPR) Instrument The BI-2000 SPR instrument produces superior, high-quality data at a completely affordable price. BI-SPR technology utilizes a unique detection technology that delivers high sensitivity and fast response times with superior versatility in a broad range of research applications. Our innovative use of interchangeable analysis modules is specially developed to fulfill a…

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GPCR dimer assays with Tag-lite® technology

Cisbio Bioassays

G-Protein Coupled Receptors (GPCRs) are common drug targets. Previously, most studies were based on the monomeric model, but this perception of GPCRs is now evolving towards homodimeric , heterodimeric and oligomeric models. To facilitate research into GPCR dimers, CisBio Bioassays has applied the Tag-lite® technology to GPCR interaction assays. Based on HTRF® technology, plasmids have been designed to express either the SNA…

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GPCR ligand binding with Tag-lite technology

Cisbio Bioassays

Cisbio Bioassays offer a comprehensive cellular platform to develop HTRF® ligand binding assays.Features: • Single technology and cellular platform for all GPCR assays • Unique non-radioactive ligand binding assays • Miniaturization down to < 10µl • Peptidic and non-peptidic fluorescent ligands • High Specific Binding • Low Non-Specific Binding with HTRF technology Tag-lite fluorescent ligands available for (Feb10): Vasopre…

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Tag-lite® cell-lines and reagents, a multimodal environment streamlined for GPCR studies

Cisbio Bioassays

Tag-lite® cell-lines and reagents, a multimodal environment streamlined for GPCR studies. Cellular trans-membrane receptors are high potential therapeutic targets in pharmacological research, among them G-Protein Coupled Receptors (GPCRs). To reach a better physiological understanding, their study is deepening and is now focusing on structural assessments (ligand binding, dimerisation) and also on multiple signal pathway assa…

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DIVERSet Diversity Libraries

ChemBridge Corporation

Structurally diverse small molecule libraries with broad 3D pharmacophore coverage for hit identification ChemBridge offers two, complementary DIVERSet™ Libraries, each composed of 50,000 leadlike and druglike compounds. Both DIVERSet Libraries (the DIVERSet-EXP and the DIVERSet-CL) are designed to provide the greatest coverage of pharmacophore space within 50,000 compounds while maintaining chemical structure diversity. Th…

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NimbleGen Gene Expression Microarray

Roche

Roche NimbleGen provides a unique combination of high-density arrays, long-oligo probes, and flexible design capability that together provide superior results for advanced gene expression analysis. NimbleGen microarrays enable accurate, sensitive, and specific interrogation of genome-wide expression for any sequenced and annotated genome. Researchers also can tile through a genome at any desired spacing to discover genome-wide…

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BlueScreen HC - S9

Gentronix Ltd.

BlueScreen HC uses a single cell strain, which permits 8 compounds to be tested across 8 dilutions (2-fold serial), together with untreated and positive controls, in one 96-well microplate. After arraying test compounds and dilutions, growing cells are added to each well. For studies without S9 metabolic activation data are collected after incubation (48h) using a multimode microplate reader. For studies incorporating S9 metab…

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Strep-tag® Starter Kit

IBA BioTAGnology

The Strep-tag® / Strep-Tactin® purification system allows the isolation of above 95% pure and functional proteins after one chromatographical step. The Strep-tag system is based on the highly selective and easily controllable interaction between the Strep-tag II peptide and the specially engineered streptavidin called Strep-Tactin. The binding affinity of Strep-tag II to Strep-Tactin is nearly 100 times higher than to Stre…

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FasL-Strep Apoptosis Assays

IBA BioTAGnology

FasL-Strep, a stable homotrimer, efficiently induces the CD95 pathway of apoptosis and is highly suited for evaluation of CD95 (Fas) receptor-ligand interaction. Human or murine FasL-Strep (CD95L-T4) is an engineered human or murine Fas (CD95) ligand. C-terminal fusion of the T4-FOLDON to the extracellular FasL (CD95L) receptor-binding domain (E142-L281) results in bioactive, conformationally stabilized, well defined trimers…

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Strep-Tactin® Superflow®

IBA BioTAGnology

The recently launched Strep-Tactin® Superflow® high capacity resin offers improved binding capacity but identical high protein purity compared to standard Strep-Tactin® Superflow®. Thus, it is the perfect solution for Strep-tag® protein purification. Both Strep-Tactin® Superflow® resins • combine outstanding flow characteristics with superior mechanical stability • are suitable for increased flow rates and useful for purificat…

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Agilent Drug Discovery Services: HTS

Agilent’s contract Lead Discovery Service utilizes label-free RapidFire technology for direct quantitation of a wide range of native analytes across diverse therapeutic areas. Supports SAR programs via retesting of hits. Uses your existing assays or RapidFire custom-developed assays. Quick data turnaround for faster drug discovery decisions.Screened as singletons or compressed format The ideal candidate assays are often the sa…

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HybSelect Sequence Capture and Sequencing Service

febit holding GmbH

Specify the genes you want to capture, and ship your genomic DNA samples to febit. febit’s experts will capture your region of interest with our HybSelect technology and send back the captured DNA to you with suggestions for the sequencing run on your SOLiD 3 system or your Illumina GAII system. Benefits • Short turn around time • Fast probe design • Available catalog Biochips for detection of cancer genes • Excellent enrichme…

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febit’s microRNA profiling service

febit holding GmbH

Fast service from sample to ready-to-publish data • Up-to-date miRNA arrays based on the latest miRBase version (http://www.mirbase.org/) • Flexible and fast array design for customized biochips • From sample submission to data results report in 2–3 weeks Comprehensive analysis report of your data for publication-ready results • Sample amount: only 130 ng total RNA needed

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