HTS Libraries
R&D Systems Recombinant Human LDL RThe low density lipoprotein receptor (LDLR) is the founding member of the LDLR family of scavenger receptors. This family contains transmembrane molecules that are characterized by the presence of EGF repeats, complement-like repeats, and YWTD motifs that form β-propellers. Specifications and Use for R&D LDL RSource of R&D LDL R• A DNA sequence encoding the signal peptide from human CD33 was…
R&D M-CSF - Recombinant Mouse Protein M-CSF, also known as CSF-1, is the primary regulator of macrophage survival, proliferation and differentiation and is essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis.…
R&D PDGF BB, CF - Recombinant PDGF-BB Human Protein Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the α-granules of platelets activated during the coagulation of blood to form serum. Specifications and Use of R&D PDGFSource of of R&D PDGF • A DNA sequence encoding the 109 amino acid residue mature human PDGF-B chain p…
R&D Systems - Recombinant Human Bone morphogenetic protein 2 (BMP-2) Bone morphogenetic protein 2 (BMP-2)is a member of the BMP subgroup of the TGF-β superfamily. It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration.Specifications and Use of R&D BMP-2R&D BMP-2 Source • The DNA sequence encoding human BMP-2 (Wozney, J. et al., 1988, Science 242…
R&D Systems - Recombinant Human HGF (NS0-expressed)HGF, also known as Hepatopoietin A, was initially identified as a potent mitogen for hepatocytes in primary culture. Subsequently, HGF was also shown to be mitogenic for a variety of cell types including endothelial and epithelial cells, melanocytes, and keratinocytes. Specifications and Use of R&D HGFSource of R&D human HGF • A DNA sequence encoding the 728 amino acid residu…
R&D Systems Recombinant Human IL-1 beta/IL-1F2 IL-1 is a name that designates two pleiotropic cytokines, IL-1α (IL-1F1) and IL-1β (IL-1F2), which are the products of distinct genes. IL-1α and IL-1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. S…
R&D Systems Recombinant Human IL-2 Interleukin-2 (IL-2) is a O-glycosylated, four α-helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Specifications and Use of R&D IL-2 Source • A DNA sequence encoding the mature human IL-2 protein sequence (Taniguchi et al., 1983, Nature 302: 305 - 310; Ma…
R&D Systems Recombinant Human FGF basic (157 aa)FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 35 - 60% amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. This factor contains four cysteine residues, but reduced FGF basic retains fu…
TGF- β1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-β superfamily that share a characteristic cystine knot structure.1 - 7 TGF-β1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Specifications and Use for R&D TGF-beta1Source •…
R&D Systems Recombinant Human HGFHGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE-like domain, four Kringle domains, and a serine proteinase-like domain that has no detectable protease activity. Specifications and Use of R&D HGF Source of R&D HGF• A DNA sequence encoding the 728 am…
Say goodbye to secondary antibodies – Go direct using the World’s Easiest DIY Antibody Labeling Kit - Lightning-Link™! • Eliminates need for secondary antibodies • Reduces the number of wash steps • Ideal for multi-protein analysis – with over 40 available labels • Very easy to use • 100% antibody recovery Lightning-Link™ kits The DIY Lightning-Link™ kit allows you to label an antibody with minimal hands-on time - less than 30…
The ASIC1a gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC1a channels expressed in neurons are therapeutic targets for treatment of pain and depression. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN2 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 ce…
The ACCN1 gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC2a channels expressed in neurons are therapeutic targets for treatment of pain. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN1 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growt…
The ACCN31 gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC3 channels expressed in neurons are therapeutic targets for treatment of pain. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN3 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growt…
Human Cav2.2/β3/α2δ1 ion channel-expressing, division-arrested cells (CHO-K1). Cat#: CT4159. Three vials of Cyropreserved irradiated cells, 2x10E6 cells/vial (6x10E6 cells total). Platform validation: PatchXpress®
The human CACNA1B gene encodes the pore-forming subunit of voltage-gated N-type Ca2+ channels. Co-expression with the β3 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav2.2 channels, widely distributed in neurons, are therapeutic targets in neuropathic and inflammatory pain. Synonyms: N-type calcium channel Host cell: CHO-K1, division-arrested Gene name: CACNA1B/CACNB3/CACNA2D1 My…
The HCN4 gene encodes the pore-forming subunit of a hyperpolarization-gated, cyclic nucleotide-sensitive, non-selective cation channel. HCN4 channels expressed in the heart contribute to the pacemaker current (Ih) and are therapeutic targets for treatment of cardiac ischemia and angina. Synonyms: hyperpolarization-activated, cyclic nucleotide-gated channel Host cell: CHO-K1, division-arrested Gene name: HCN4 Mycoplasma status…
The human KCNA3 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Kv1.3 channels expressed in lymphocytes are therapeutic targets in autoimmune diseases. Synonyms: hKv1.3 Host cell: CHO-K1, division-arrested Gene name: KCNA3 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth…
The human KCNQ1 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Co-expression with minK, an auxiliary subunit, recapitulates native function in heterologous expression (CHO cells). KvLQT1/minK channels expressed in the heart are safety targets in congenital and acquired long QT syndromes. Synonyms: Kv7.1/minK Host cell: CHO-K1, division-arrested Gene name: KCNQ1/KCNE1 Mycoplasma status: Negative (M…
The human KCNQ4 gene encodes the pore-forming subunit of a voltage-gated potassium channel. KCNQ4 channels expressed in CNS neurons are therapeutic targets in epilepsy. Synonyms: Kv7.4 Host cell: CHO-K1, division-arrested Gene name: KCNQ4 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteris…
The KCNH2 gene encodes the pore-forming subunit of a voltage-gated potassium channel. HERG channels expressed in cardiac muscle cells are safety targets; hERG inhibition has been linked to drug induced prolongation of the QT interval and torsade de pointes (a potentially lethal cardiac arrhythmia). Synonyms: Kv11.1 Host cell: CHO-K1, division-arrested Gene name: KCNH2 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Thr…
The human SCN1A gene encodes the pore-forming subunit of voltage-gated type-1 Na+ channels. Neuronal Nav1.1 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-1 sodium channel Host cell: CHO-K1 Gene name: SCN1A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth char…
The human Nav1.2 gene encodes the pore-forming subunit of voltage-gated type-2 Na+ channels. Neuronal Nav1.2 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-2 sodium channel Host cell: CHO-K1 Gene name: SCN2A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth cha…
The SCN3A gene encodes the pore-forming subunit of the voltage-gated type-3 Na+ channel. Neuronal Nav1.3 channels are therapeutic targets in seizure and pain. Synonyms: brain type-3 sodium channel Host cell: CHO-K1, division-arrested Gene name: SCN3A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth…
The SCN4A gene encodes the pore-forming subunit of the voltage-gated, skeletal muscle Na+ channel. Nav1.4 is a therapeutic target for treatment of myotonia. Synonyms: Skeletal muscle sodium channel, SkM1 Host cell: CHO-K1, division-arrested Gene name: SCN4A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS…
