Scale-up Products & Reviews

25

Scale-Up is generally defined as the process of transferring the results of the discovery phases of the drug discovery process, obtained on a laboratory scale, to the pilot plant and finally to production scale. Scale-Up uses reactors and pump systems as well as reagents, standards and buffers. Often Scale-Up is provided as a service by Contract Manufacturing Organizations (CMOs).

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Celigo S Image Cytometer

A micro-well, plate-based multi-channel bright field and 3 fluorescent channels imaging cytometer for 2D and 3D culture using both adherent and suspension cells.

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rCPC

RotaChrom

Our engineers designed the rCPC platform for pilot-scale purification tasks within a laboratory environment. It is ideal for all batch sizes, smaller or larger, or campaign type of research work, and continuous-batch production. To accommodate a user-friendly operation, RotaChrom offers a turn-key solution package for semi-automated solvent handling (preparation and recovery) upon request. rCPC can be utilized as an at-line p…

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iCPC

RotaChrom

RotaChrom’s iCPC platform is the largest commercially available Centrifugal Partition Chromatography instrument in the world. Designed for industrial-scale purification projects in continuous batch operation mode, this device is by far the most cost-effective industrial-scale chromatography platform available on the market. It has the capacity to process hundreds of kilograms of crude input material per month.The iCPC uses si…

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pCPC

RotaChrom

The pCPC is a tailor-made system by RotaChrom. It is a combination of the iCPC and a solvent preparation, recovery and regeneration system. It also delivers a proprietary automated biphasic solvent system preparation platform, providing a continuous feed to our iCPC instrument.pCPC encompasses a fully integrated production platform where complete solvent handling is provided beside the iCPC’s purification solutions. The syste…

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pCPC + HeiVap Platform

RotaChrom

Add even more to your production with pCPC combined with the Heivap platform. This is a complex solution which enables complete solvent handling and allows the elimination of solvents and final polish of the product. The strategic partnership RotaChrom entered into with Heidolph comes with the possibility to combine the pCPC with Heidolph Heivap platform.  The scaled-up and extended system provides a versatile solution, while…

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Thermo Scientific™ Pharma16 Twin-Screw Extruder

Thermo Fisher Scientific

Rapidly develop pharmaceutical formulations and adopt continuous processing methods using the Pharma 16 Twin-Screw Extruder. It can switch between continuous hot melt extrusion (HME) or wet granulation (TSG) with ease. Optimize drug process development parameters with less time and effort than batch processes and easily scale-up to larger Thermo Scientific extruders using minimal amounts of expensive APIs and excipients. 

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Evolve® Process Columns

Astrea Bioseparations

Evolve ® Process Columns have been designed specifically for use in biopharmaceutical applications. Available in eight diameters, Evolve ® Process Columns provide cost effective, scalable, high performance technology suitable for use in both pilot and production scale chromatographic processes.

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