The Endosafe®-PTS is a handheld spectrophotometer that utilizes FDA-licensed disposable cartridges for accurate, convenient endotoxin testing. With test results in just 15 minutes, you can rapidly move forward with your study or the next step in your process. The PTS is so easy-to-use, you can run the test in just three simple steps: Enter your sample ID into the system’s memory using the keypad Add your sample to the disposab…
This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010. Model Properties: Coat Color: Hairless, albino background…
The Endosafe ® nexgen-PTS™ is a rapid, point-of-use handheld spectrophotometer that uses USP/BET-compliant disposable cartridges for accurate, convenient, and real-time endotoxin testing, glucan concentration determination, and Gram identification. With its small benchtop footprint, the Endosafe ® nexgen-PTS™ is ideal for small to mid-size pharmaceutical companies and compounding pharmacies that want a portable, real-time t…
What if you could test more product with less time? Utilizing the same FDA-licensed LAL cartridge technology as the Endosafe® nexgen-PTS™, the multi-cartridge benchtop endotoxin testing instrument addresses the need for higher sample throughput. The Endosafe ® nexgen-MCS™ is capable of concurrently testing up to five samples within 15 minutes for fast, quantitative, and accurate endotoxin results.
Congenic Strain Production Congenic strains are widely used in biomedical research because they reduce genetic variability and provide insight into the contribution of genetic background to phenotype. Congenic strains are identical at all genetic loci except for one; that differing locus is usually the transgene or knock-out region of interest. Utilizing traditional, random backcrossing methods, it takes 10 generations (upw…
The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes. Model Properties: Coat Color: Black Ideal For: Cardiac hypertrophy, heart failure Strain Code: 510 HE,…
NSE-p25 mice were created by pronuclear injection of an NSE-p25 transgene, produced internally at Pfizer, with transplantation of embryos to pseudopregnant CD-1 females. At weaning genomic DNA was isolated from tail tissue and founder transgenics were identified by PCR that specifically amplified DNA sequences from the human p25 cDNA. Founder mice were bred to FVB/N mates and transgenic offspring were used to maintain the tra…
Developed by C.C. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Strains 6 and 10 separated about 1937. To Hall in 1948 from The Jackson Laboratory. To NIH in 1951 from The Jackson Laboratory at F32. To Charles River in 1974 from NIH. Model Properties: Coat Color: Black MHC Haplotype: H2b Ideal For: general multipurpose model, diet-induced obesity, transgenic…
Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976. Model Properties: Coat Color: Non-agouti brown MHC Haplotype: RT1n Ideal For: Geneti…
The New Zealand White rabbit was obtained in 1991 by Charles River Canada (CRC) from Kitayama Labs K.K. of Nagano Prefecture, Japan. Model Properties: Coat Color: White (albino) Ideal For: General multipurpose model Strain Code: 052
