Drug discovery > Target Discovery Products & Reviews

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Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.

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Magna ChIP™ Protein A Magnetic Beads

Merck

Recombinant protein A covalently bound to magnetic beads. These beads provide users a rapid, reproducible and efficient reagent for collecting immunocomplexes for chromatin immunoprecipitations (ChIP) assays. Compared with conventional protein A agarose beads, protein A magnetic beads significantly reduce the handling time and mechanical stress on target immunocomplexes.

4.3/5.0
|1 Review

Anti-Citrulline (Modified) Detection Kit

Merck

This kit provides the reagents required for the detection of citrulline-containing proteins by Western blot analysis with the anti-Citrulline antibody. Detection is a two-step process in which citrulline-containing proteins immobilized on nitrocellulose or PVDF are formaldehyde-cross linked to the membrane to improve protein retention, followed by modification of citrulline residues with 2,3-butanedione monoxime and antipyrine…

4.3/5.0
|1 Review

ChIPAb+ EZH2, clone AC22

Merck

The ChIPAb+ EZH2, clone AC22 antibody/primer set includes the EZH2, clone AC22 antibody, a negative control antibody (purified mouse IgG), and qPCR primers which amplify a 135 bp region within the promoter of the human MYT-1 gene. The EZH2, clone AC22 antibody and negative control antibodies are supplied in a scalable "per ChIP" reaction size and can be used to functionally validate the precipitation of EZH2-associated chromat…

4.3/5.0
|1 Review



AKT1 STAR ELISA Kit

Merck

The UPSTATE colorimetric STAR (Signal Transduction Assay Reaction) ELISA kit is a solid phase sandwich enzyme linked immunosorbent assay that provides a fast, sensitive method to detect specific levels of signaling targets in whole cell extracts. The AKT1 plate is coated with a specific mouse monoclonal anti-AKT1 capture antibody on the microwells of the 96-well clear plate. Many of the reagents are supplied in ready-to use fo…

3.7/5.0
|1 Review


Amicon Ultra-15 Centrifugal Filter Units

Merck

• High recovery Ultracel regenerated cellulose membrane in a range of molecular weight cut-offs• High retentate recovery of >90%• Vertical membrane reduces concentration polarization for ultra-fast spin times (as fast as 10–15 minutes)• Heat-sealed membrane minimizes downstream extractables• 100% integrity tested for reliable performance• Convenient sample monitoring with translucent housing and volume gradations• Direct pipet…

4.3/5.0
|8 Reviews

Amicon® Ultra-4 Centrifugal Filter Units

Merck

• High recovery Ultracel regenerated cellulose membrane in a range of molecular weight cut-offs• High retentate recovery of >90%• Vertical membrane reduces concentration polarization for ultra-fast spin times (as fast as 5 minutes)• Heat-sealed membrane minimizes downstream extractables• 100% integrity tested for reliable performance• Convenient sample monitoring with translucent housing and volume gradations• Direct pipette s…

4.4/5.0
|3 Reviews



ViBE BioAnalyzer

BioScale, Inc.

The compact, benchtop ViBE BioAnalyzer is the ideal research tool for assay development or small to medium size studies which require highly-sensitive detection and quantitation of proteins in complex biological mixtures with real-time results. The small foot-print BioAnalyzer can be easily scaled-up to a ViBE Workstation for higher throughput and walk-away operation. The ViBE BioAnalyzer   •  Ideal for research applications a…

4.3/5.0
|1 Review

Flowsight® Imaging Flow Cytometer

Merck

The FlowSight flow cytometer offers high performance in a small package. Its innovative design increases signal and minimizes noise to provide unmatched fluorescence sensitivity. Twelve standard detection channels simultaneously produce brightfield, darkfield and up to ten channels of fluorescence imagery of every cell. With these unique capabilities, the FlowSight enables a broad range of applications. Intuitive: Easy-to-use,…

3.7/5.0
|1 Review

FDSS7000

Hamamatsu Photonic Systems Corp.

The FDSS7000, the top-rated model , includes new features including 1536 dispensing tips and multiple wash tanks. The FDSS7000 continues to offer real-time kinetic analysis of various types of both nonadherent and adherent cells. The FDSS7000 offers field upgradable components including the 'FRET attachment', robotics integration, additional heads, and more allow for a customized system for you now and in the future. Features…

4.4/5.0
|2 Reviews

Nucleofector® II Device

Lonza Group Ltd

The basic Nucleofector® II Device is a single cuvette based system that has been used in research labs since 2001. It allows efficient transfection of hard-to-transfect cell lines and primary cells with different substrates, e.g. DNA vectors or siRNA oligonucleotides, in low throughput format. What benefits are important for your work? Efficient transfection in single cuvette format? Up to 90% efficiency with plasmid DNA…

4.2/5.0
|6 Reviews

i6000TM

BioGenex Laboratories

The i6000TM Automated Staining System is a sophisticated instrument and can process slides for Immunohistochemistry (IHC). It is a walk-away automation which provides high throughput, unsurpassed speed and versatility. The i6000TM Automated Staining System is designed for clinical diagnostics and research laboratories. The system operates in both closed and open modes, for maximum flexibility of work flow with standardized pro…

3.7/5.0
|1 Review

CytoOne 35 x 10 mm TC dish

USA Scientific, Inc.

CytoOne 35 x 10 mm TC dish, 10/sleeve, 300/case Beveled outer edges help you grasp CytoOne 35 x 10 mm dishes without accidentally displacing the lids. Tissue culture treatment promotes optimum cell attachment and growth. Growth area: 9.6 cm2; working volume: 2 ml; inner diameter: 3.5 cm. • Sturdy, flat bases resist bowing and warping • Optical clarity provides distortion-free microscopy • Vented lids improve gas exchange • Sta…

3.9/5.0
|3 Reviews


Fermentas* TurboFect* Protein Transfection Reagent

Thermo Fisher Scientific

In combination with the included Enhancer Solution, the reagent efficiently delivers functionally active proteins, antibodies and peptides into the cytoplasm of cells. Proteins of different sizes and net charge (different pI) can be delivered into various cell types, including primary, adherent and suspension cells (see Fig. 1, 2 and list of cells below). The reagent can be used in the presence or absence of serum. TurboFect P…

4.3/5.0
|1 Review

Yeastmaker Yeast Transformation System 2

Clontech Laboratories, Inc.

The Yeastmaker Yeast Transformation System 2 provides a high-efficiency polyethylene glycol (PEG)/LiAc-based method for preparing and transforming competent yeast cells. The Yeast Transformation System 2 protocol provides a higher and more reliable transformation efficiency than many other commonly used methods as a result of specially formulated "YPD Plus" recovery medium, which results in more surviving transformed colonies…

4.0/5.0
|1 Review

Sciclone® G3 NGS Workstation

Revvity

The Sciclone ® G3 NGSx workstation is a complete benchtop solution for the automated construction of up to or greater than 96 libraries per day.                  

4.0/5.0
|1 Review

AD1520  Aspirate and Dispense Platform

BioDot Inc.

The AD1520™ is a tabletop workstation designed for high speed aspirating and dispensing applications to glass slides, microtiter plates or membranes. The system is compatible with multiple dispensing technologies, has nest options and can be customized to meet application needs making it ideal for a research laboratory to investigate new applications.

3.7/5.0
|1 Review

Advanced 2-colour Fluorescence Microarray Scanner: InnoScan 710

Innopsys

Reliability, speed, traceability. Characterised by its ease-of-use, speed and image quality, the InnoScan 710 from Innopsys is an ideal tool for routine microarray reading. Supplied with a validation slide and associated Mapix software, full compatibility with traceability standards is assured.InnoScan 710 has a special feature of using a real-time autofocus system that offers the advantage of making it insensitive to substra…

4.3/5.0
|3 Reviews

L1523: Classic Laboratory Fermentor

BiOENGiNEERiNG

The classically designed, yet never duplicated laboratory fermentor: Universally designed for a wide-range of applications with low operating costs Medium volumes can be produced even if there is no steam available in your lab Consistent design philosophy, the concept has never been modified since its existence although others have certainly tried to replicate it Available in a steel head-glass cylinder or steel head…

4.0/5.0
|1 Review

Bio-Plex® 200 System

Bio-Rad

100–240 V, multiplex array system, includes reader, microplate platform, Bio-Plex Manager 5.0 software, PC, calibration kit, validation kit 4.0, MCV plate IV, reservoir, sheath fluid, 2 sample needles

4.3/5.0
|5 Reviews